Synthesis of trisubstituted pyrimidines by regioselective S<sub>N</sub>Ar and Suzuki reactions of polyhalopyrimidines

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Synlett 2006 861.pdf (71.3 KB)

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ICR Authors

Collins, Ian

Authors

Large, JM
Clarke, M
Williamson, DM
McDonald, E
Collins, A

Document Type

Journal Article

Date

2006-04-04

Date Accepted

2006-03-13

Abstract

An efficient, regioselective approach to the synthesis of trisubstituted pyrimidines was developed. Sequential functionalization of com. available polyhalopyrimidines provided the target compds. in moderate to good overall yields.

Citation

SYNLETT, 2006, (6), pp. 861 - 864 (4)

DOI

10.1055/s-2006-939050

URI

https://repository.icr.ac.uk/handle/internal/322

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Source Title

Publisher

GEORG THIEME VERLAG KG

ISSN

0936-5214

eISSN

1437-2096

Collections

Cancer Therapeutics

Research Team

Medicinal Chemistry 2

Notes