AXIN Shapes Tankyrase ARChitecture.

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Embargo End Date

Authors

Guettler, S

Document Type

Journal Article

Date

2016-10-04

Date Accepted

2016-09-20

Abstract

The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat region of Tankyrase and discuss potential implications for enzymatic substrate modification.

Citation

Structure (London, England : 1993), 2016, 24 (10), pp. 1625 - 1627

Rights

Source Title

Publisher

CELL PRESS

ISSN

0969-2126

eISSN

1878-4186

Research Team

Structural Biology of Cell Signalling

Notes