AXIN Shapes Tankyrase ARChitecture.
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Embargo End Date
ICR Authors
Authors
Guettler, S
Document Type
Journal Article
Date
2016-10-04
Date Accepted
2016-09-20
Abstract
The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat region of Tankyrase and discuss potential implications for enzymatic substrate modification.
Citation
Structure (London, England : 1993), 2016, 24 (10), pp. 1625 - 1627
Rights
Source Title
Publisher
CELL PRESS
ISSN
0969-2126
eISSN
1878-4186
Collections
Research Team
Structural Biology of Cell Signalling