Mendelian randomisation study of smoking exposure in relation to breast cancer risk.
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ICR Authors
Authors
Park, HA
Neumeyer, S
Michailidou, K
Bolla, MK
Wang, Q
Dennis, J
Ahearn, TU
Andrulis, IL
Anton-Culver, H
Antonenkova, NN
Arndt, V
Aronson, KJ
Augustinsson, A
Baten, A
Beane Freeman, LE
Becher, H
Beckmann, MW
Behrens, S
Benitez, J
Bermisheva, M
Bogdanova, NV
Bojesen, SE
Brauch, H
Brenner, H
Brucker, SY
Burwinkel, B
Campa, D
Canzian, F
Castelao, JE
Chanock, SJ
Chenevix-Trench, G
Clarke, CL
NBCS Collaborators,
Conroy, DM
Couch, FJ
Cox, A
Cross, SS
Czene, K
Daly, MB
Devilee, P
Dörk, T
Dos-Santos-Silva, I
Dwek, M
Eccles, DM
Eliassen, AH
Engel, C
Eriksson, M
Evans, DG
Fasching, PA
Flyger, H
Fritschi, L
García-Closas, M
García-Sáenz, JA
Gaudet, MM
Giles, GG
Glendon, G
Goldberg, MS
Goldgar, DE
González-Neira, A
Grip, M
Guénel, P
Hahnen, E
Haiman, CA
Håkansson, N
Hall, P
Hamann, U
Han, S
Harkness, EF
Hart, SN
He, W
Heemskerk-Gerritsen, BAM
Hopper, JL
Hunter, DJ
ABCTB Investigators,
kConFab Investigators,
Jager, A
Jakubowska, A
John, EM
Jung, A
Kaaks, R
Kapoor, PM
Keeman, R
Khusnutdinova, E
Kitahara, CM
Koppert, LB
Koutros, S
Kristensen, VN
Kurian, AW
Lacey, J
Lambrechts, D
Le Marchand, L
Lo, W-Y
Lubiński, J
Mannermaa, A
Manoochehri, M
Margolin, S
Martinez, ME
Mavroudis, D
Meindl, A
Menon, U
Milne, RL
Muranen, TA
Nevanlinna, H
Newman, WG
Nordestgaard, BG
Offit, K
Olshan, AF
Olsson, H
Park-Simon, T-W
Peterlongo, P
Peto, J
Plaseska-Karanfilska, D
Presneau, N
Radice, P
Rennert, G
Rennert, HS
Romero, A
Saloustros, E
Sawyer, EJ
Schmidt, MK
Schmutzler, RK
Schoemaker, MJ
Schwentner, L
Scott, C
Shah, M
Shu, X-O
Simard, J
Smeets, A
Southey, MC
Spinelli, JJ
Stevens, V
Swerdlow, AJ
Tamimi, RM
Tapper, WJ
Taylor, JA
Terry, MB
Tomlinson, I
Troester, MA
Truong, T
Vachon, CM
van Veen, EM
Vijai, J
Wang, S
Wendt, C
Winqvist, R
Wolk, A
Ziogas, A
Dunning, AM
Pharoah, PDP
Easton, DF
Zheng, W
Kraft, P
Chang-Claude, J
Neumeyer, S
Michailidou, K
Bolla, MK
Wang, Q
Dennis, J
Ahearn, TU
Andrulis, IL
Anton-Culver, H
Antonenkova, NN
Arndt, V
Aronson, KJ
Augustinsson, A
Baten, A
Beane Freeman, LE
Becher, H
Beckmann, MW
Behrens, S
Benitez, J
Bermisheva, M
Bogdanova, NV
Bojesen, SE
Brauch, H
Brenner, H
Brucker, SY
Burwinkel, B
Campa, D
Canzian, F
Castelao, JE
Chanock, SJ
Chenevix-Trench, G
Clarke, CL
NBCS Collaborators,
Conroy, DM
Couch, FJ
Cox, A
Cross, SS
Czene, K
Daly, MB
Devilee, P
Dörk, T
Dos-Santos-Silva, I
Dwek, M
Eccles, DM
Eliassen, AH
Engel, C
Eriksson, M
Evans, DG
Fasching, PA
Flyger, H
Fritschi, L
García-Closas, M
García-Sáenz, JA
Gaudet, MM
Giles, GG
Glendon, G
Goldberg, MS
Goldgar, DE
González-Neira, A
Grip, M
Guénel, P
Hahnen, E
Haiman, CA
Håkansson, N
Hall, P
Hamann, U
Han, S
Harkness, EF
Hart, SN
He, W
Heemskerk-Gerritsen, BAM
Hopper, JL
Hunter, DJ
ABCTB Investigators,
kConFab Investigators,
Jager, A
Jakubowska, A
John, EM
Jung, A
Kaaks, R
Kapoor, PM
Keeman, R
Khusnutdinova, E
Kitahara, CM
Koppert, LB
Koutros, S
Kristensen, VN
Kurian, AW
Lacey, J
Lambrechts, D
Le Marchand, L
Lo, W-Y
Lubiński, J
Mannermaa, A
Manoochehri, M
Margolin, S
Martinez, ME
Mavroudis, D
Meindl, A
Menon, U
Milne, RL
Muranen, TA
Nevanlinna, H
Newman, WG
Nordestgaard, BG
Offit, K
Olshan, AF
Olsson, H
Park-Simon, T-W
Peterlongo, P
Peto, J
Plaseska-Karanfilska, D
Presneau, N
Radice, P
Rennert, G
Rennert, HS
Romero, A
Saloustros, E
Sawyer, EJ
Schmidt, MK
Schmutzler, RK
Schoemaker, MJ
Schwentner, L
Scott, C
Shah, M
Shu, X-O
Simard, J
Smeets, A
Southey, MC
Spinelli, JJ
Stevens, V
Swerdlow, AJ
Tamimi, RM
Tapper, WJ
Taylor, JA
Terry, MB
Tomlinson, I
Troester, MA
Truong, T
Vachon, CM
van Veen, EM
Vijai, J
Wang, S
Wendt, C
Winqvist, R
Wolk, A
Ziogas, A
Dunning, AM
Pharoah, PDP
Easton, DF
Zheng, W
Kraft, P
Chang-Claude, J
Document Type
Journal Article
Date
2021-10-12
Date Accepted
2021-04-28
Abstract
BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. METHODS: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. RESULTS: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 × 10-2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. CONCLUSION: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
Citation
British journal of cancer, 2021, 125 (8), pp. 1135 - 1145
Source Title
Publisher
SPRINGERNATURE
ISSN
0007-0920
eISSN
1532-1827
Research Team
Aetiological Epidemiology