Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).
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ICR Authors
Authors
Biganzoli, L
Battisti, NML
Wildiers, H
McCartney, A
Colloca, G
Kunkler, IH
Cardoso, M-J
Cheung, K-L
de Glas, NA
Trimboli, RM
Korc-Grodzicki, B
Soto-Perez-de-Celis, E
Ponti, A
Tsang, J
Marotti, L
Benn, K
Aapro, MS
Brain, EGC
Battisti, NML
Wildiers, H
McCartney, A
Colloca, G
Kunkler, IH
Cardoso, M-J
Cheung, K-L
de Glas, NA
Trimboli, RM
Korc-Grodzicki, B
Soto-Perez-de-Celis, E
Ponti, A
Tsang, J
Marotti, L
Benn, K
Aapro, MS
Brain, EGC
Document Type
Journal Article
Date
2021-07-01
Date Accepted
2020-12-02
Abstract
Breast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficient evidence specific to older adults. Decision making should not be driven by age alone but should involve geriatric assessments plus careful consideration of life expectancy, competing risks of mortality, and patient preferences. A multidisciplinary taskforce, including members of the European Society of Breast Cancer Specialists and International Society of Geriatric Oncology, gathered to expand and update the previous 2012 evidence-based recommendations for the management of breast cancer in older individuals with the endorsement of the European Cancer Organisation. These guidelines were expanded to include chemotherapy toxicity prediction calculators, cultural and social considerations, surveillance imaging, genetic screening, gene expression profiles, neoadjuvant systemic treatment options, bone-modifying drugs, targeted therapies, and supportive care. Recommendations on geriatric assessment, ductal carcinoma in situ, screening, primary endocrine therapy, surgery, radiotherapy, adjuvant systemic therapy, and secondary breast cancer were updated.
Citation
The Lancet. Oncology, 2021, 22 (7), pp. e327 - e340
Source Title
Publisher
ELSEVIER SCIENCE INC
ISSN
1470-2045
eISSN
1474-5488
Collections
Research Team
Breast Cancer Clinical Research
Breast Cancer Clinical Research
Breast Cancer Clinical Research