SLiM-binding pockets: an attractive target for broad-spectrum antivirals.
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Embargo End Date
ICR Authors
Authors
Simonetti, L
Nilsson, J
McInerney, G
Ivarsson, Y
Davey, NE
Nilsson, J
McInerney, G
Ivarsson, Y
Davey, NE
Document Type
Journal Article
Date
2023-01-07
Date Accepted
2022-12-15
Abstract
Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broad-spectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.
Citation
Trends in Biochemical Sciences, 2023, pp. S0968-0004(22)00332-2 -
Source Title
Trends in Biochemical Sciences
Publisher
CELL PRESS
ISSN
0968-0004
eISSN
Collections
Research Team
Short Linear Motif