Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy: A "Game Changer" for Prostate Treatment?
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Embargo End Date
ICR Authors
Authors
Pathmanathan, AU
van As, NJ
Kerkmeijer, LGW
Christodouleas, J
Lawton, CAF
Vesprini, D
van der Heide, UA
Frank, SJ
Nill, S
Oelfke, U
van Herk, M
Li, XA
Mittauer, K
Ritter, M
Choudhury, A
Tree, AC
van As, NJ
Kerkmeijer, LGW
Christodouleas, J
Lawton, CAF
Vesprini, D
van der Heide, UA
Frank, SJ
Nill, S
Oelfke, U
van Herk, M
Li, XA
Mittauer, K
Ritter, M
Choudhury, A
Tree, AC
Document Type
Journal Article
Date
2018-02-01
Date Accepted
2017-10-12
Abstract
Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.
Citation
International journal of radiation oncology, biology, physics, 2018, 100 (2), pp. 361 - 373
Source Title
Publisher
ELSEVIER SCIENCE INC
ISSN
0360-3016
eISSN
1879-355X
Collections
Research Team
Radiotherapy Physics Modelling
Stereotactic and Precision Body Radiotherapy
Stereotactic and Precision Body Radiotherapy