Immunotherapy Sensitivity of Mismatch Repair-Deficient Cancer: Mutation Load Is Not Enough.
Loading...
Embargo End Date
ICR Authors
Authors
Gerlinger, M
Document Type
Journal Article
Date
2021-01-11
Date Accepted
2020-12-07
Abstract
Abundant neoantigens are considered responsible for the immunotherapy sensitivity of mismatch repair-deficient (MMRd) cancers. In this issue of Cancer Cell, two papers show that MLH1 mismatch repair gene loss promotes cGAS-STING activation, interferon secretion, and T cell priming. This may be essential for the high immunotherapy sensitivity in MMRd cancer.
Citation
Cancer cell, 2021, 39 (1), pp. 16 - 18
Source Title
Publisher
CELL PRESS
ISSN
1535-6108
eISSN
1878-3686
Collections
Research Team
Translational Oncogenomics
Translational Oncogenomics
Translational Oncogenomics