OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
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ICR Authors
Authors
Röst, HL
Sachsenberg, T
Aiche, S
Bielow, C
Weisser, H
Aicheler, F
Andreotti, S
Ehrlich, H-C
Gutenbrunner, P
Kenar, E
Liang, X
Nahnsen, S
Nilse, L
Pfeuffer, J
Rosenberger, G
Rurik, M
Schmitt, U
Veit, J
Walzer, M
Wojnar, D
Wolski, WE
Schilling, O
Choudhary, JS
Malmström, L
Aebersold, R
Reinert, K
Kohlbacher, O
Sachsenberg, T
Aiche, S
Bielow, C
Weisser, H
Aicheler, F
Andreotti, S
Ehrlich, H-C
Gutenbrunner, P
Kenar, E
Liang, X
Nahnsen, S
Nilse, L
Pfeuffer, J
Rosenberger, G
Rurik, M
Schmitt, U
Veit, J
Walzer, M
Wojnar, D
Wolski, WE
Schilling, O
Choudhary, JS
Malmström, L
Aebersold, R
Reinert, K
Kohlbacher, O
Document Type
Journal Article
Date
2016-08-30
Date Accepted
2016-06-27
Abstract
High-resolution mass spectrometry (MS) has become an important tool in the life sciences, contributing to the diagnosis and understanding of human diseases, elucidating biomolecular structural information and characterizing cellular signaling networks. However, the rapid growth in the volume and complexity of MS data makes transparent, accurate and reproducible analysis difficult. We present OpenMS 2.0 (http://www.openms.de), a robust, open-source, cross-platform software specifically designed for the flexible and reproducible analysis of high-throughput MS data. The extensible OpenMS software implements common mass spectrometric data processing tasks through a well-defined application programming interface in C++ and Python and through standardized open data formats. OpenMS additionally provides a set of 185 tools and ready-made workflows for common mass spectrometric data processing tasks, which enable users to perform complex quantitative mass spectrometric analyses with ease.
Citation
Nature methods, 2016, 13 (9), pp. 741 - 748
Source Title
Publisher
NATURE PORTFOLIO
ISSN
1548-7091
eISSN
1548-7105