Critical parameters in targeted drug development: the pharmacological audit trail.
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Embargo End Date
ICR Authors
Authors
Banerji, U
Workman, P
Workman, P
Document Type
Journal Article
Date
2016-08-01
Date Accepted
2015-10-23
Abstract
The Pharmacological Audit Trail (PhAT) comprises a set of critical questions that need to be asked during discovery and development of an anticancer drug. Key aspects include: (1) defining a patient population; (2) establishing pharmacokinetic characteristics; (3) providing evidence of target engagement, pathway modulation, and biological effect with proof of concept pharmacodynamic biomarkers; (4) determining intermediate biomarkers of response; (5) assessing tumor response; and (6) determining how to overcome resistance by combination or sequential therapy and new target/drug discovery. The questions asked in the PhAT should be viewed as a continuum and not used in isolation. Different drug development programmes derive different types of benefit from these questions. The PhAT is critical in making go-no-go decisions in the development of currently studied drugs and will continue to be relevant to discovery and development of future generations of anticancer agents.
Citation
Seminars in oncology, 2016, 43 (4), pp. 436 - 445
Source Title
Publisher
W B SAUNDERS CO-ELSEVIER INC
ISSN
0093-7754
eISSN
1532-8708
Collections
Research Team
Clinical Pharmacology – Adaptive Therapy
Medicine Drug Development Unit (de Bono)
Medicine Drug Development Unit (de Bono)