The molecular map of CLL and Richter's syndrome.
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ICR Authors
Authors
Sud, A
Parry, EM
Wu, CJ
Parry, EM
Wu, CJ
Document Type
Journal Article
Date
2024-01-23
Date Accepted
2024-01-20
Abstract
Clonal expansion of B-cells, from the early stages of monoclonal B-cell lymphocytosis through to chronic lymphocytic leukemia (CLL), and then in some cases to Richter's syndrome (RS) provides a comprehensive model of cancer evolution, notable for the marked morphological transformation and distinct clinical phenotypes. High-throughput sequencing of large cohorts of patients and single-cell studies have generated a molecular map of CLL and more recently, of RS, yielding fundamental insights into these diseases and of clonal evolution. A selection of CLL driver genes have been functionally interrogated to yield novel insights into the biology of CLL. Such findings have the potential to impact patient care through risk stratification, treatment selection and drug discovery. However, this molecular map remains incomplete, with extant questions concerning the origin of the B-cell clone, the role of the TME, inter- and intra-compartmental heterogeneity and of therapeutic resistance mechanisms. Through the application of multi-modal single-cell technologies across tissues, disease states and clinical contexts, these questions can now be addressed with the answers holding great promise of generating translatable knowledge to improve patient care.
Citation
Seminars in Hematology, 2024, pp. S0037-1963(24)00009-X -
Source Title
Seminars in Hematology
Publisher
W B SAUNDERS CO-ELSEVIER INC
ISSN
0037-1963
eISSN
1532-8686
1532-8686
1532-8686
1532-8686
1532-8686
Collections
Research Team
Cancer Genomics