Contrasting Features of Papillary and Chromophobe Renal Cell Carcinoma Revealed by Whole-Genome Sequencing.
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Authors
Culliford, R
Mills, C
Chubb, D
Kinnersley, B
Sud, A
Cornish, AJ
Browning, L
Lawrence, SED
Bentham, R
Frangou, A
Gruber, AJ
Litchfield, K
Wedge, DC
Larkin, J
Turajlic, S
Houlston, RS
Mills, C
Chubb, D
Kinnersley, B
Sud, A
Cornish, AJ
Browning, L
Lawrence, SED
Bentham, R
Frangou, A
Gruber, AJ
Litchfield, K
Wedge, DC
Larkin, J
Turajlic, S
Houlston, RS
Document Type
Journal Article
Date
2026-05-04
Date Accepted
2026-01-15
Abstract
UNLABELLED: The identification of cancer drivers is a cornerstone to the delivery of precision oncology. So far, sequencing of renal cell cancer (RCC) has largely been confined to the clear cell subtype of RCC. In contrast, sequencing analyses of the less common forms of RCC, papillary RCC (pRCC) and chromophobe RCC (ChRCC), have so far been limited. We analyzed whole-genome sequencing data on 164 tumor-normal pairs from the Genomics England 100,000 Genomes Project, providing a comprehensive, high-resolution map of copy number alterations, structural variation, and key global genomic features, including mutational signatures, intratumor heterogeneity, and analysis of extrachromosomal DNA formation. Our research establishes correlations between genomic alterations and histologic diversification and the extent to which genetically-mediated immune escape contributes to the development of these RCC subtypes. IMPLICATIONS: We demonstrate the distinctive genetics that characterizes pRCC and ChRCC and how this information has the potential to inform patient treatment and clinical trials.
Citation
Molecular Cancer Research, 2026, pp. OF1 - OF10
Source Title
Molecular Cancer Research
Publisher
AMER ASSOC CANCER RESEARCH
ISSN
1541-7786
eISSN
1557-3125
Collections
Research Team
Cancer Genomics
Directorate Clin Studies
Directorate Clin Studies