Hyperglycaemia following immune checkpoint inhibitor therapy-Incidence, aetiology and assessment.
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Embargo End Date
ICR Authors
Authors
Mulla, K
Farag, S
Moore, B
Matharu, S
Young, K
Larkin, J
Popat, S
Morganstein, DL
Farag, S
Moore, B
Matharu, S
Young, K
Larkin, J
Popat, S
Morganstein, DL
Document Type
Journal Article
Date
2023-04-01
Date Accepted
2023-01-23
Abstract
AIMS: We systematically studied the presence of hyperglycaemia during treatment with Immune Checkpoint Inhibitors (ICPI) for cancer, in those with and without diabetes at baseline, and determined the cause of new-onset hyperglycaemia, METHODS: Retrospective review of electronic records of those receiving an ICPI for melanoma, lung or renal cancer. RESULTS: Overall, 959 participants were included. In this study, 103 had diabetes at baseline (10.7%). Those with lung cancer had the highest frequency of diabetes; 131 people had hyperglycaemia (defined as at least one glucose ≥11.1 mmol/L) in the year after starting an ICPI. The incidence was 55% in those with diabetes at baseline, and 8.6% in those without baseline diabetes. Among 74 with new-onset hyperglycaemia (without pre-existing diabetes) 76% was attributable to steroid induced diabetes, with 9.5% due to ICPI Induced diabetes resembling type 1 diabetes. CONCLUSIONS: Hyperglycaemia is common in persons receiving an ICPI for cancer, including 8.6% of those without known diabetes. While much of this is due to glucocorticoid use, care is needed to avoid missing those with ICPI-induced diabetes who are at risk of diabetic ketoacidosis, which is a medical emergency.
Citation
Diabetic Medicine, 2023, 40 (4), pp. e15053 -
Source Title
Diabetic Medicine
Publisher
WILEY
ISSN
0742-3071
eISSN
1464-5491
1464-5491
1464-5491