Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome.
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Embargo End Date
ICR Authors
Authors
Dawson, H
Smrke, A
Ellery, PM
Wilkinson, N
Rosenthal, AN
McVeigh, TP
Smrke, A
Ellery, PM
Wilkinson, N
Rosenthal, AN
McVeigh, TP
Document Type
Journal Article
Date
2021-09-15
Date Accepted
2021-09-08
Abstract
PTEN is a tumour suppressor gene involved in regulating cell division. Pathogenic germline variants in PTEN predispose to benign and malignant growths of numerous organs, including of the breast. In the following report, we describe the first documented case of a fibroadenoma developing in ectopic breast tissue of the vulva in a patient with a germline pathogenic variant in PTEN. This highlights the risk of hyperplasia developing in any breast tissue, including rare ectopic sites, particularly in patients with underlying germline variants in cancer susceptibility genes.
Citation
Familial cancer, 2021
Source Title
Publisher
SPRINGER
ISSN
1389-9600
eISSN
1573-7292
1573-7292
1573-7292
Collections
Research Team
Cancer Genetics Education & Quality Improvement