Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
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Embargo End Date
ICR Authors
Authors
Hiley, C
de Bruin, EC
McGranahan, N
Swanton, C
de Bruin, EC
McGranahan, N
Swanton, C
Document Type
Other
Date
2014
Date Accepted
Abstract
The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
Citation
GENOME BIOLOGY, 2014, 15
Source Title
Publisher
BIOMED CENTRAL LTD
ISSN
1474-760X