HPV testing as a triage for borderline or mild dyskaryosis on cervical cytology: results from the Sentinel Sites study
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Embargo End Date
ICR Authors
Authors
Kelly, RS
Patnick, J
Kitchener, HC
Moss, SM
Grp, NHSCSPHPVSI
Patnick, J
Kitchener, HC
Moss, SM
Grp, NHSCSPHPVSI
Document Type
Journal Article
Date
2011-09-27
Date Accepted
Abstract
BACKGROUND: Earlier pilot studies of human papillomavirus (HPV) triage concluded that HPV triage was feasible and cost-effective. The aim of the present study was to study the impact of wider rollout of HPV triage for women with low-grade cytology on colposcopy referral and outcomes. METHODS: Human papillomavirus testing of liquid-based cytology (LBC) samples showing low-grade abnormalities was used to select women for colposcopy referral at six sites in England. Samples from 10 051 women aged 25-64 years with routine call or recall cytology reported as borderline or mild dyskaryosis were included. RESULTS: Human papillomavirus-positive rates were 53.7% in women with borderline cytology and 83.9% in those with mild dyskaryosis. The range between sites was 34.8-73.3% for borderline cytology, and 73.4-91.6% for mild dyskaryosis. In the single site using both LBC technologies there was no difference in rates between the two technologies. The positive predictive value of an HPV test was 16.3% for CIN2 or worse and 6.1% for CIN3 or worse, although there was considerable variation between sites. CONCLUSION: Triaging women with borderline cytological abnormalities and mild dyskaryosis with HPV testing would allow approximately a third of these women to be returned immediately to routine recall, and for a substantial proportion to be referred for colposcopy without repeat cytology. Variation in HPV-positive rates results in differing colposcopy workload. British Journal of Cancer (2011) 105, 983-988. doi:10.1038/bjc.2011.326 www.bjcancer.com Published online 6 September 2011 (C) 2011 Cancer Research UK
Citation
BRITISH JOURNAL OF CANCER, 2011, 105 pp. 983 - 988
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
0007-0920
eISSN
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Research Team
Cancer Screening Evaluation Unit (DoH)