The biology and treatment of leiomyosarcomas.
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ICR Authors
Authors
Kerrison, WGJ
Thway, K
Jones, RL
Huang, PH
Thway, K
Jones, RL
Huang, PH
Document Type
Journal Article
Date
2023-04-01
Date Accepted
2023-03-04
Abstract
Leiomyosarcoma (LMS) is a soft tissue sarcoma of smooth muscle origin that can arise in multiple anatomical sites and is broadly classified as extra-uterine LMS or uterine LMS. There is substantial interpatient heterogeneity within this histological subtype, and despite multi-modal therapy, clinical management remains challenging with poor patient prognosis and few new therapies available. Here we discuss the current treatment landscape of LMS in both the localised and advanced disease setting. We further describe the latest advances in our evolving understanding of the genetics and biology of this group of heterogeneous diseases and summarise the key studies delineating the mechanisms of acquired and intrinsic chemotherapy resistance in this histological subtype. We conclude by providing a perspective on how novel targeted agents such as PARP inhibitors may usher in a new paradigm of biomarker-driven therapies that will ultimately impact the outcomes of patients with LMS.
Citation
Critical Reviews in Oncology Hematology, 2023, 184 pp. 103955 -
Source Title
Critical Reviews in Oncology Hematology
Publisher
ELSEVIER SCIENCE INC
ISSN
1040-8428
eISSN
1879-0461
1879-0461
1879-0461
Collections
Research Team
Mol and Systems Oncology