Mechanical and Systems Biology of Cancer.
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Embargo End Date
ICR Authors
Authors
Spill, F
Bakal, C
Mak, M
Bakal, C
Mak, M
Document Type
Journal Article
Date
2018-01-01
Date Accepted
2018-07-11
Abstract
Mechanics and biochemical signaling are both often deregulated in cancer, leading toincreased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell tension, stiffness, and engagement with the extracellular environment, which can lead to extracellular matrix remodeling. Intracellular mechanics can alter signaling and transcription factors, impacting cell decision making. Additionally, signaling from soluble and mechanical factors in the extracellular environment, such as substrate stiffness and ligand density, can modulate cytoskeletal dynamics. Computational models closely integrated with experimental support, incorporating cancer-specific parameters, can provide quantitative assessments and serve as predictive tools toward dissecting the feedback between signaling and mechanics and across multiple scales and domains in tumor progression.
Citation
Computational and structural biotechnology journal, 2018, 16 pp. 237 - 245
Source Title
Publisher
ELSEVIER SCIENCE BV
ISSN
2001-0370
eISSN
2001-0370
Collections
Research Team
Dynamical Cell Systems