Regions of homozygosity as risk factors for multiple myeloma.
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ICR Authors
Authors
Went, M
Sud, A
Li, N
Johnson, DC
Mitchell, JS
Kaiser, M
Houlston, RS
Sud, A
Li, N
Johnson, DC
Mitchell, JS
Kaiser, M
Houlston, RS
Document Type
Journal Article
Date
2019-07-01
Date Accepted
2019-01-31
Abstract
Genomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly different. However, one ROH at chromosome 9q21, harboring the B-cell transcription factor gene KLF9, showed evidence of a consistent association and may therefore warrant further investigation as a candidate risk factor for MM. Overall, our analysis provides little support for a homozygosity signature being a significant factor in MM risk.
Citation
Annals of human genetics, 2019, 83 (4), pp. 231 - 238
Source Title
Publisher
WILEY
ISSN
0003-4800
eISSN
1469-1809
Collections
Research Team
Cancer Genomics
Myeloma Group
Myeloma Group