Epidemiology, genetics and treatment of multiple myeloma and precursor diseases.
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ICR Authors
Authors
Hemminki, K
Försti, A
Houlston, R
Sud, A
Försti, A
Houlston, R
Sud, A
Document Type
Journal Article
Date
2021-12-15
Date Accepted
2021-07-26
Abstract
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 people being diagnosed with MM per year. Whereas 5-year survival after a diagnosis of MM has improved from 28% in 1975 to 56% in 2012, the disease remains essentially incurable. In this review, we summarize our current understanding of MM including its epidemiology, genetics and biology. We will also provide an overview of MM management that has led to improvements in survival, including recent changes to diagnosis and therapies. Areas of unmet need include the management of patients with high-risk MM, those with reduced performance status and those refractory to standard therapies. Ongoing research into the biology and early detection of MM as well as the development of novel therapies, such as immunotherapies, has the potential to influence MM practice in the future.
Citation
International Journal of Cancer
DOI
Source Title
Publisher
WILEY
ISSN
0020-7136
eISSN
Collections
Research Team
Cancer Genomics
Cancer Genomics
Cancer Genomics