Landscape of transcriptomic interactions between breast cancer and its microenvironment.
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Embargo End Date
ICR Authors
Authors
Fox, NS
Haider, S
Harris, AL
Boutros, PC
Haider, S
Harris, AL
Boutros, PC
Document Type
Journal Article
Date
2019-07-15
Date Accepted
2019-06-04
Abstract
Solid tumours comprise mixtures of tumour cells (TCs) and tumour-adjacent cells (TACs), and the intricate interconnections between these diverse populations shape the tumour's microenvironment. Despite this complexity, clinical genomic profiling is typically performed from bulk samples, without distinguishing TCs from TACs. To better understand TC-TAC interactions, we computationally distinguish their transcriptomes in 1780 primary breast tumours. We show that TC and TAC mRNA abundances are divergently associated with clinical phenotypes, including tumour subtypes and patient survival. These differences reflect distinct responses of TCs and TACs to specific somatic driver mutations, particularly TP53. These data further elucidate how the molecular interplay between breast tumours and their microenvironment drives aggressive tumour phenotypes.
Citation
Nature communications, 2019, 10 (1), pp. 3116 - ?
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
2041-1723
eISSN
2041-1723