Proteomic and Metabolomic Profiling in Soft Tissue Sarcomas.
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Embargo End Date
ICR Authors
Authors
Chadha, M
Huang, PH
Huang, PH
Document Type
Journal Article
Date
2022-02-16
Date Accepted
2021-12-04
Abstract
Advances in proteomic and metabolomic technologies have accelerated our understanding of multiple aspects of cancer biology across distinct tumour types. Here we review the current state-of-the-art in the use of proteomics and metabolomics in soft tissue sarcomas. We highlight the utility of these Omics-based methodologies to identify new drug targets, synthetic lethal interactions, candidate therapeutics and novel biomarkers to facilitate patient stratification. Due to the unbiased and global nature of these profiling methods to assess the levels of protein expression, post-translational modifications such as phosphorylation and glycosylation as well as key metabolites, many of these findings have broad applications not just in specific histotypes but across multiple STS subtypes. Specific examples of proteomic and metabolomic findings that have led to the development of early phase clinical trials of investigational agents will be discussed. While promising, the use of these technologies in the study of sarcoma is still limited, and there is a need for further research in this area. In particular, it would be important to integrate these approaches with other Omics strategies such as genomics and epigenomics as well as implement these tools alongside clinical trials in order to maximize the impact of these tools on our biological understanding and treatment of this group of rare diseases of unmet need.
Citation
Current Treatment Options in Oncology, 2022, 23 (1), pp. 78 - 88
Source Title
Current Treatment Options in Oncology
Publisher
SPRINGER
ISSN
1527-2729
eISSN
1534-6277
1534-6277
1534-6277
Collections
Research Team
Mol and Systems Oncology