Browsing by author "Daley, Frances"
Now showing items 1-4 of 4
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Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma.
Kuczynski, EA; Yin, M; Bar-Zion, A; Lee, CR; Butz, H; et al. (OXFORD UNIV PRESS INC, 2016-04-08)BACKGROUND: The anti-angiogenic Sorafenib is the only approved systemic therapy for advanced hepatocellular carcinoma (HCC). However, acquired resistance limits its efficacy. An emerging theory to explain intrinsic resistance ... -
SOX11 promotes invasive growth and ductal carcinoma in situ progression.
Oliemuller, E; Kogata, N; Bland, P; Kriplani, D; Daley, F; et al. (WILEY, 2017-10-01)Here, we show that SOX11, an embryonic mammary marker that is normally silent in postnatal breast cells, is expressed in many oestrogen receptor-negative preinvasive ductal carcinoma in situ (DCIS) lesions. Mature mammary ... -
Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models.
Bridgeman, VL; Vermeulen, PB; Foo, S; Bilecz, A; Daley, F; et al. (WILEY, 2017-02-01)Anti-angiogenic therapies have shown limited efficacy in the clinical management of metastatic disease, including lung metastases. Moreover, the mechanisms via which tumours resist anti-angiogenic therapies are poorly ... -
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases.
Frentzas, S; Simoneau, E; Bridgeman, VL; Vermeulen, PB; Foo, S; et al. (NATURE PUBLISHING GROUP, 2016-11-01)The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of through the induction of angiogenesis, tumor vascularization can occur through the ...