• Systemic therapies in advanced epithelioid haemangioendothelioma: A retrospective international case series from the World Sarcoma Network and a review of literature. 

  Frezza, AM; Ravi, V; Lo Vullo, S; Vincenzi, B; Tolomeo, F; Chen, TW-W; Teterycz, P; Baldi, GG; Italiano, A; Penel, N; Brunello, A; Duffaud, F; Hindi, N; Iwata, S; Smrke, A; Fedenko, A; Gelderblom, H; Van Der Graaf, W; Vozy, A; Connolly, E; Grassi, M; Benjamin, RS; Broto, J-M; Grignani, G; Jones, RL; Kawai, A; Tysarowski, A; Mariani, L; Casali, PG; Stacchiotti, S

  <h4>Background</h4>This observational, retrospective effort across Europe, US, Australia, and Asia aimed to assess the activity of systemic therapies in EHE, an ultra-rare sarcoma, marked by WWTR1-CAMTA1 or YAP1-TFE3 ...
• Phase III Study to Evaluate Efficacy and Safety of Andecaliximab With mFOLFOX6 as First-Line Treatment in Patients With Advanced Gastric or GEJ Adenocarcinoma (GAMMA-1). 

  Shah, MA; Bodoky, G; Starodub, A; Cunningham, D; Yip, D; Wainberg, ZA; Bendell, J; Thai, D; He, J; Bhargava, P; Ajani, JA

  <h4>Purpose</h4>Andecaliximab (ADX) is a monoclonal antibody that inhibits matrix metalloproteinase 9, an extracellular enzyme involved in matrix remodeling, tumor growth, and metastases. A phase I and Ib study of modified ...
• Diagnostic accuracy of deep learning in medical imaging: a systematic review and meta-analysis. 

  Aggarwal, R; Sounderajah, V; Martin, G; Ting, DSW; Karthikesalingam, A; King, D; Ashrafian, H; Darzi, A (2021-04-07)

  Deep learning (DL) has the potential to transform medical diagnostics. However, the diagnostic accuracy of DL is uncertain. Our aim was to evaluate the diagnostic accuracy of DL algorithms to identify pathology in medical ...
• Clinicopathological features and treatment outcome of oesophageal gastrointestinal stromal tumour (GIST): A large, retrospective multicenter European study. 

  Mohammadi, M; IJzerman, NS; Hohenberger, P; Rutkowski, P; Jones, RL; Martin-Broto, J; Gronchi, A; Schöffski, P; Vassos, N; Farag, S; Baia, M; Oosten, AW; Steeghs, N; Desar, IME; Reyners, AKL; van Sandick, JW; Bastiaannet, E; Gelderblom, H; Schrage, Y (2021-03-31)

  <h4>Background</h4>Oesophageal gastrointestinal stromal tumours (GISTs) account for ≤1% of all GISTs. Consequently, evidence to guide clinical decision-making is limited.<h4>Methods</h4>Clinicopathological features and ...
• Cediranib in addition to chemotherapy for women with relapsed platinum-sensitive ovarian cancer (ICON6): overall survival results of a phase III randomised trial. 

  Ledermann, JA; Embleton-Thirsk, AC; Perren, TJ; Jayson, GC; Rustin, GJS; Kaye, SB; Hirte, H; Oza, A; Vaughan, M; Friedlander, M; González-Martín, A; Deane, E; Popoola, B; Farrelly, L; Swart, AM; Kaplan, RS; Parmar, MKB; ICON6 collaborators

  <h4>Background</h4>Cediranib, an oral anti-angiogenic VEGFR 1-3 inhibitor, was studied at a daily dose of 20 mg in combination with platinum-based chemotherapy and as maintenance in a randomised trial in patients with first ...

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