• Automatic reconstruction of the delivered dose of the day using MR-linac treatment log files and online MR imaging. 

  Menten, MJ; Mohajer, JK; Nilawar, R; Bertholet, J; Dunlop, A; Pathmanathan, AU; Moreau, M; Marshall, S; Wetscherek, A; Nill, S; Tree, AC; Oelfke, U (2020-01-10)

  BACKGROUND AND PURPOSE:Anatomical changes during external beam radiotherapy prevent the accurate delivery of the intended dose distribution. Resolving the delivered dose, which is currently unknown, is crucial to link ...
• A causal mechanism for childhood acute lymphoblastic leukaemia. 

  Greaves, M (2018-08)

  In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation ...
• Phospho-proteomics and functional genomics for the characterisation of resistance mechanisms to agents targeting the EGFR, PI3K and MAPK pathways and their application in guiding drug combinations in colorectal cancer 

  Georgiou, A (2019-12-31)

  KRAS mutant and RAS/BRAF wild type (RAS WT) colorectal cancer (CRC) cells respond differently to targeted agents, as exemplified by cetuximab, an anti-EGFR antibody, which is only effective in a proportion of patients with ...
• Molecular characterisation and functional assessment of FGFR3 mutations in cancer 

  Carvalho Lima, N (2020-01-31)

  Genetic alterations such as mutations in the Fibroblast Growth Factor Receptors (FGFRs) family play important roles in the development and progression of several cancer types. How these mutations affect protein function ...
• Ubiquitin-mediated regulation of necroptosis 

  Ramos Garcia, L (2020-01-31)

  Regulated cell death is a fundamental cellular process that is critical for the development and survival of multicellular organisms. Cell death and inflammation are essential to restore tissue homeostasis following tissue ...

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