• A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients. 

  Sadanandam, A; Bopp, T; Dixit, S; Knapp, DJHF; Emperumal, CP; Vergidis, P; Rajalingam, K; Melcher, A; Kannan, N (2020-12-08)

  COVID-19 patients show heterogeneity in clinical presentation and outcomes that makes pandemic control and strategy difficult; optimizing management requires a systems biology approach of understanding the disease. Here ...
• Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. 

  Hewitt, G; Borel, V; Segura-Bayona, S; Takaki, T; Ruis, P; Bellelli, R; Lehmann, LC; Sommerova, L; Vancevska, A; Tomas-Loba, A; Zhu, K; Cooper, C; Fugger, K; Patel, H; Goldstone, R; Schneider-Luftman, D; Herbert, E; Stamp, G; Brough, R; Pettitt, S; Lord, CJ; West, SC; Ahel, I; Ahel, D; Chapman, JR; Deindl, S; Boulton, SJ (2020-12-15)

  Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair ...
• Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE). 

  Crabb, SJ; Danson, S; Catto, JWF; Hussain, S; Chan, D; Dunkley, D; Downs, N; Marwood, E; Day, L; Saunders, G; Light, M; Whitehead, A; Ellis, D; Sarwar, N; Enting, D; Birtle, A; Johnson, B; Huddart, R; Griffiths, G (2021-01-20)

  <h4>Purpose</h4>Preclinical data indicate that DNA methyltransferase inhibition will circumvent cisplatin resistance in various cancers.<h4>Patient and methods</h4>SPIRE comprised a dose-escalation phase for incurable ...
• Treatment outcomes for small cell carcinoma of the bladder: results from a UK patient retrospective cohort study. 

  Chau, C; Rimmer, Y; Choudhury, A; Leaning, D; Law, A; Enting, D; Lim, JH; Hafeez, S; Khoo, V; Huddart, R; Mitchell, D; Henderson, DR; McGrane, J; Beresford, M; Vasudev, N; Beesley, S; Hilman, S; Manetta, C; Sriram, R; Sharma, A; Eswar, C; Treece, S; Vilarino-Varela, M; Varughese, M; H Glen; Pintus, E; Crabb, S (2021-02-06)

  <h4>Background</h4>Small cell carcinoma of the bladder (SCCB) is rare, accounting for under 1% of all bladder carcinomas. It is aggressive and outcomes are poor due to early metastatic spread. Owing to its rarity, there ...
• Clinical and co-clinical genomics of paediatric solid tumours with a special focus in DIPG 

  Izquierdo Delgado, E (2020-07-31)

  Cure rates for paediatric solid cancers have not improved in the last decade. Delivering precision medicine to stratify patients based on their molecular profiling is a key goal to support existing and upcoming adaptive ...

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