This is a database of the academic work published by our staff and students. The full text of many of our journal articles is available free of charge from this website. Older publications are currently available at https://publications.icr.ac.uk
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The biological treatment of renal-cell carcinoma and melanoma
(2002)Summary Biological therapies are claiming a place in the routine management of some solid tumours. In this review we focus on the biological treatment of melànoma and renal-cell carcinoma, identifying the background to ... -
Breakpoints in the ataxia telangiectasia gene arise at the RGYW somatic hypermutation motif
(2002-01-17)The mature sporadic T-cell malignancy, T-cell prolymphocytic leukemia (T-PLL) is remarkable for frequently harbouring somatic mutations of the Ataxia Telangiectasia (A-T) gene, ATM. Because some data suggest ATM is frequently ... -
Ethical approval for multicentre clinical trials in children: contrasting systems in three European countries
(2002-05)Pan-European collaboration in studies of novel therapies and treatment strategies in childhood cancer is playing an increasing role in the attempt to improve cure rates. Differences in the systems of various Countries with ... -
Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein
(2002-05-01)Transcription factor GATA-2 Is Implicated in the survival and growth of multipotential progenitors. Here we report that the promyelocytic leukemia zinc finger (PLZF) protein can Interact with GATA-2 and can modify Its ... -
Congenital alveolar rhabdomyosarcoma - Clinical and molecular distinction from alveolar rhabdomyosarcoma in older children
(2001-02-01)BACKGROUND, Congenital alveolar rhabdomyosarcoma (RMS) is extremely rare and invariably fatal with current therapy. Its clinical presentation is unusual and is distinct from RMS in older children, with > 50% of patients ...
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