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  • Rapid 4D-MRI reconstruction using a deep radial convolutional neural network: Dracula. 

    Freedman, JN; Gurney-Champion, OJ; Nill, S; Shiarli, A-M; Bainbridge, HE; Mandeville, HC; Koh, D-M; McDonald, F; Kachelrieß, M; Oelfke, U; Wetscherek, A
    <h4>Background and purpose</h4>4D and midposition MRI could inform plan adaptation in lung and abdominal MR-guided radiotherapy. We present deep learning-based solutions to overcome long 4D-MRI reconstruction times while ...
  • MobiDB: intrinsically disordered proteins in 2021. 

    Piovesan, D; Necci, M; Escobedo, N; Monzon, AM; Hatos, A; Mičetić, I; Quaglia, F; Paladin, L; Ramasamy, P; Dosztányi, Z; Vranken, WF; Davey, NE; Parisi, G; Fuxreiter, M; Tosatto, SCE
    The MobiDB database (URL: provides predictions and annotations for intrinsically disordered proteins. Here, we report recent developments implemented in MobiDB version 4, regarding the database format, ...
  • Incidence of accidental awareness during general anaesthesia in obstetrics: a multicentre, prospective cohort study. 

    Odor, PM; Bampoe, S; Lucas, DN; Moonesinghe, SR; Andrade, J; Pandit, JJ; Pan-London Peri-operative Audit and Research Network (PLAN), for the DREAMY Investigators Group (2021-01-12)
    General anaesthesia for obstetric surgery has distinct characteristics that may contribute towards a higher risk of accidental awareness during general anaesthesia. The primary aim of this study was to investigate the ...
  • Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy. 

    Kottke, T; Tonne, J; Evgin, L; Driscoll, CB; van Vloten, J; Jennings, VA; Huff, AL; Zell, B; Thompson, JM; Wongthida, P; Pulido, J; Schuelke, MR; Samson, A; Selby, P; Ilett, E; McNiven, M; Roberts, LR; Borad, MJ; Pandha, H; Harrington, K; Melcher, A; Vile, RG (2021-03-26)
    In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by aggressive relapse. We show here that VSV-IFNβ-escape tumors ...
  • Tipifarnib in Head and Neck Squamous Cell Carcinoma With <i>HRAS</i> Mutations. 

    Ho, AL; Brana, I; Haddad, R; Bauman, J; Bible, K; Oosting, S; Wong, DJ; Ahn, M-J; Boni, V; Even, C; Fayette, J; Flor, MJ; Harrington, K; Kim, S-B; Licitra, L; Nixon, I; Saba, NF; Hackenberg, S; Specenier, P; Worden, F; Balsara, B; Leoni, M; Martell, B; Scholz, C; Gualberto, A (2021-03-22)
    <h4>Purpose</h4>Mutations in the <i>HRAS</i> (m<i>HRAS</i>) proto-oncogene occur in 4%-8% of patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Tipifarnib is a farnesyltransferase ...

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