• Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells. 

  Pepe, F; Pagotto, S; Soliman, S; Rossi, C; Lanuti, P; Braconi, C; Mariani-Costantini, R; Visone, R; Veronese, A (2017-05-08)

  The miR-483-3p is upregulated in several tumors, including liver tumors, where it inhibits TP53-dependent apoptosis by targeting the pro-apoptotic gene BBC3/PUMA. The transcriptional regulation of the miR-483-3p could be ...
• Is breast seroma after tumour resection associated with patient-reported breast appearance change following radiotherapy? Results from the IMPORT HIGH (CRUK/06/003) trial 

  Bhattacharya, I; Haviland, JS; Gulliford, S; Harris, E; Bliss, J; Kirby, A
• Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma. 

  Lupini, L; Pepe, F; Ferracin, M; Braconi, C; Callegari, E; Pagotto, S; Spizzo, R; Zagatti, B; Lanuti, P; Fornari, F; Ghasemi, R; Mariani-Costantini, R; Bolondi, L; Gramantieri, L; Calin, GA; Sabbioni, S; Visone, R; Veronese, A; Negrini, M (2016-05)

  The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in ...
• MicroRNA 31-3p expression and benefit from anti-EGFR inhibitors in metastatic colorectal cancer patients enrolled in the prospective phase II PROSPECT-C trial. 

  Anandappa, G; Lampis, A; Cunningham, D; Khan, KH; Kouvelakis, K; Vlachogiannis, G; Hedayat, S; Tunariu, N; Rao, S; Watkins, D; Starling, N; Braconi, C; Darvish Damavandi, M; Lote, H; Thomas, J; Peckitt, C; Kalaitzaki, E; Khan, N; Fotiadis, N; Rugge, M; Begum, R; Rana, I; Bryant, A; Hahne, JC; Chau, I; Fassan, M; Valeri, N (2019-04-05)

  PURPOSE: Anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibodies (mABs) are effective in the treatment of metastatic colorectal cancer (mCRC) patients. RAS status and tumour location (sidedness) are predictive ...
• miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis. 

  Fassan, M; Cui, R; Gasparini, P; Mescoli, C; Guzzardo, V; Vicentini, C; Munari, G; Loupakis, F; Lonardi, S; Braconi, C; Scarpa, M; D'Angelo, E; Pucciarelli, S; Angriman, I; Agostini, M; D'Incá, R; Farinati, F; Gafà, R; Lanza, G; Frankel, WL; Croce, CM; Valeri, N; Rugge, M (2019-02)

  miR-224 has recently emerged as a driver oncomiR in sporadic colorectal carcinogenesis, but its pathogenetic role is still controversial. A large phenotypical and molecularly characterized series of preinvasive and invasive ...

View more