• Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in Triple Negative Breast Cancer: the TNT trial. 

  Sipos, O; Tovey, H; Quist, J; Haider, S; Nowinski, S; Gazinska, P; Kernaghan, S; Toms, C; Maguire, S; Orr, N; Linn, SC; Owen, J; Gillett, C; Pinder, SE; Bliss, JM; Tutt, A; Cheang, MCU; Grigoriadis, A (2020-10-21)

  BACKGROUND:In the TNT trial of triple negative breast cancer (NCT00532727), germline BRCA1/2 mutations were present in 28% of carboplatin responders. We assessed quantitative measures of structural chromosomal instability ...
• CdTe Based Energy Resolving, X-ray Photon Counting Detector Performance Assessment: The Effects of Charge Sharing Correction Algorithm Choice. 

  Pickford Scienti, OLP; Bamber, JC; Darambara, DG (2020-10-27)

  Most modern energy resolving, photon counting detectors employ small (sub 1 mm) pixels for high spatial resolution and low per pixel count rate requirements. These small pixels can suffer from a range of charge sharing ...
• EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers. 

  Smyth, EC; Vlachogiannis, G; Hedayat, S; Harbery, A; Hulkki-Wilson, S; Salati, M; Kouvelakis, K; Fernandez-Mateos, J; Cresswell, GD; Fontana, E; Seidlitz, T; Peckitt, C; Hahne, JC; Lampis, A; Begum, R; Watkins, D; Rao, S; Starling, N; Waddell, T; Okines, A; Crosby, T; Mansoor, W; Wadsley, J; Middleton, G; Fassan, M; Wotherspoon, A; Braconi, C; Chau, I; Vivanco, I; Sottoriva, A; Stange, DE; Cunningham, D; Valeri, N (2020-11-16)

  OBJECTIVE: Epidermal growth factor receptor (EGFR) inhibition may be effective in biomarker-selected populations of advanced gastro-oesophageal adenocarcinoma (aGEA) patients. Here, we tested the association between outcome ...
• The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data. 

  Caravagna, G; Sanguinetti, G; Graham, TA; Sottoriva, A (2020-11-17)

  BACKGROUND: The large-scale availability of whole-genome sequencing profiles from bulk DNA sequencing of cancer tissues is fueling the application of evolutionary theory to cancer. From a bulk biopsy, subclonal deconvolution ...
• Tumor necrosis is significantly associated with reduced recurrence-free survival after curative resection of gastrointestinal stromal tumors. 

  Tyler, R; Davies, E; Tan, D; Hodson, J; Taniere, P; Thway, K; Jafri, M; Almond, M; Ford, S; Strauss, D; Hayes, A; Smith, M; Desai, A (2020-11-10)

  BACKGROUND OBJECTIVES:The impact of tumor necrosis as a prognostic factor in gastrointestinal stromal tumor (GISTs) is still debated. The objective was to determine whether tumor necrosis is an independent risk factor for ...

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