• Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial. 

  Joharatnam-Hogan, N; Hatem, D; Cafferty, FH; Petrucci, G; Cameron, DA; et al. (SPRINGERNATURE, 2023-09-07)

  BACKGROUND: Pre-clinical models demonstrate that platelet activation is involved in the spread of malignancy. Ongoing clinical trials are assessing whether aspirin, which inhibits platelet activation, can prevent or delay ...
• MRI Apparent Diffusion Coefficient (ADC) as a Biomarker of Tumour Response: Imaging-Pathology Correlation in Patients with Hepatic Metastases from Colorectal Cancer (EORTC 1423). 

  Jackson, A; Pathak, R; deSouza, NM; Liu, Y; Jacobs, BKM; et al. (MDPI, 2023-07-12)

  Background: Tumour apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (MRI) is a putative pharmacodynamic/response biomarker but the relationship between drug-induced effects on the ADC ...
• Recommendations for improved reproducibility of ADC derivation on behalf of the Elekta MRI-linac consortium image analysis working group. 

  Bisgaard, ALH; Keesman, R; van Lier, ALHMW; Coolens, C; van Houdt, PJ; et al. (Elsevier BV, 2023-09-01)

  BACKGROUND AND PURPOSE: The apparent diffusion coefficient (ADC), a potential imaging biomarker for radiotherapy response, needs to be reproducible before translation into clinical use. The aim of this study was to evaluate ...
• Individual Participant Data Network Meta-Analysis of Neoadjuvant Chemotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Junction Carcinoma. 

  Faron, M; Cheugoua-Zanetsie, M; Tierney, J; Thirion, P; Nankivell, M; et al. (American Society of Clinical Oncology (ASCO), 2023-07-12)

  PURPOSE: The optimal neoadjuvant treatment for resectable carcinoma of the thoracic esophagus (TE) or gastroesophageal junction (GEJ) remains a matter of debate. We performed an individual participant data (IPD) network ...
• Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation. 

  Barone, C; Orsenigo, R; Cazzola, A; D'Errico, E; Patelli, A; et al. (MDPI, 2023-07-14)

  Infant acute myeloid leukemia (AML) is a heterogeneous disease, genetically distinct from its adult counterpart. Chromosomal translocations involving the KMT2A gene (MLL) are especially common in affected infants of less ...

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