• ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma. 

  Rashid, M; van der Horst, M; Mentzel, T; Butera, F; Ferreira, I; Pance, A; Rütten, A; Luzar, B; Marusic, Z; de Saint Aubain, N; Ko, JS; Billings, SD; Chen, S; Abi Daoud, M; Hewinson, J; Louzada, S; Harms, PW; Cerretelli, G; Robles-Espinoza, CD; Patel, RM; van der Weyden, L; Bakal, C; Hornick, JL; Arends, MJ; Brenn, T; Adams, DJ (2019-05-17)

  Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation and potential for malignant transformation and aggressive behaviour. We present the genomic analysis of 75 samples from 57 ...
• Analytical Validation of Multiplex Biomarker Assay to Stratify Colorectal Cancer into Molecular Subtypes. 

  Ragulan, C; Eason, K; Fontana, E; Nyamundanda, G; Tarazona, N; Patil, Y; Poudel, P; Lawlor, RT; Del Rio, M; Koo, S-L; Tan, W-S; Sclafani, F; Begum, R; Teixeira Mendes, LS; Martineau, P; Scarpa, A; Cervantes, A; Tan, IB; Cunningham, D; Sadanandam, A (2019-05-21)

  Previously, we classified colorectal cancers (CRCs) into five CRCAssigner (CRCA) subtypes with different prognoses and potential treatment responses, later consolidated into four consensus molecular subtypes (CMS). Here ...
• Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III-IV melanoma. 

  Andtbacka, RHI; Collichio, F; Harrington, KJ; Middleton, MR; Downey, G; Ӧhrling, K; Kaufman, HL (2019-06-06)

  BACKGROUND:Talimogene laherparepvec is an oncolytic immunotherapy approved in the US, Europe, Australia and Switzerland. We report the final planned analysis of OPTiM, a randomized open-label phase III trial in patients ...
• SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers. 

  Jones, GG; Del Río, IB; Sari, S; Sekerim, A; Young, LC; Hartig, N; Areso Zubiaur, I; El-Bahrawy, MA; Hynds, RE; Lei, W; Molina-Arcas, M; Downward, J; Rodriguez-Viciana, P (2019-06-10)

  Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in ...
• PhyreRisk: A Dynamic Web Application to Bridge Genomics, Proteomics and 3D Structural Data to Guide Interpretation of Human Genetic Variants. 

  Ofoegbu, TC; David, A; Kelley, LA; Mezulis, S; Islam, SA; Mersmann, SF; Strömich, L; Vakser, IA; Houlston, RS; Sternberg, MJE

  PhyreRisk is an open-access, publicly accessible web application for interactively bridging genomic, proteomic and structural data facilitating the mapping of human variants onto protein structures. A major advance over ...

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