This is a database of the academic work published by our staff and students. The full text of many of our journal articles is available free of charge from this website. Older publications are currently available at https://publications.icr.ac.uk

  • Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival. 

    Oser, MG; Fonseca, R; Chakraborty, AA; Brough, R; Spektor, A; Jennings, RB; Flaifel, A; Novak, JS; Gulati, A; Buss, E; Younger, ST; McBrayer, SK; Cowley, GS; Bonal, DM; Nguyen, Q-D; Brulle-Soumare, L; Taylor, P; Cairo, S; Ryan, CJ; Pease, EJ; Maratea, K; Travers, J; Root, DE; Signoretti, S; Pellman, D; Ashton, S; Lord, CJ; Barry, ST; Kaelin, WG (2018-10-29)
    Small cell lung cancer (SCLC) accounts for 15% of lung cancer and is almost always linked to inactivating RB1 and TP53 mutations. SCLC frequently responds, albeit briefly, to chemotherapy. The canonical function of the RB1 ...
  • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent. 

    Guo, Y; Warren Andersen, S; Shu, X-O; Michailidou, K; Bolla, MK; Wang, Q; Garcia-Closas, M; Milne, RL; Schmidt, MK; Chang-Claude, J; Dunning, A; Bojesen, SE; Ahsan, H; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Arndt, V; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Bogdanova, NV; Bonanni, B; Børresen-Dale, A-L; Brand, J; Brauch, H; Brenner, H; Brüning, T; Burwinkel, B; Casey, G; Chenevix-Trench, G; Couch, FJ; Cox, A; Cross, SS; Czene, K; Devilee, P; Dörk, T; Dumont, M; Fasching, PA; Figueroa, J; Flesch-Janys, D; Fletcher, O; Flyger, H; Fostira, F; Gammon, M; Giles, GG; Guénel, P; Haiman, CA; Hamann, U; Hooning, MJ; Hopper, JL; Jakubowska, A; Jasmine, F; Jenkins, M; John, EM; Johnson, N; Jones, ME; Kabisch, M; Kibriya, M; Knight, JA; Koppert, LB; Kosma, V-M; Kristensen, V; Le Marchand, L; Lee, E; Li, J; Lindblom, A; Luben, R; Lubinski, J; Malone, KE; Mannermaa, A; Margolin, S; Marme, F; McLean, C; Meijers-Heijboer, H; Meindl, A; Neuhausen, SL; Nevanlinna, H; Neven, P; Olson, JE; Perez, JIA; Perkins, B; Peterlongo, P; Phillips, K-A; Pylkäs, K; Rudolph, A; Santella, R; Sawyer, EJ; Schmutzler, RK; Seynaeve, C; Shah, M; Shrubsole, MJ; Southey, MC; Swerdlow, AJ; Toland, AE; Tomlinson, I; Torres, D; Truong, T; Ursin, G; Van Der Luijt, RB; Verhoef, S; Whittemore, AS; Winqvist, R; Zhao, H; Zhao, S; Hall, P; Simard, J; Kraft, P; Pharoah, P; Hunter, D; Easton, DF; Zheng, W
    BACKGROUND: Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is ...
  • Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers. 

    Schmidt, MK; Hogervorst, F; van Hien, R; Cornelissen, S; Broeks, A; Adank, MA; Meijers, H; Waisfisz, Q; Hollestelle, A; Schutte, M; van den Ouweland, A; Hooning, M; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Antoniou, AC; Arndt, V; Bermisheva, M; Bogdanova, NV; Bolla, MK; Brauch, H; Brenner, H; Brüning, T; Burwinkel, B; Chang-Claude, J; Chenevix-Trench, G; Couch, FJ; Cox, A; Cross, SS; Czene, K; Dunning, AM; Fasching, PA; Figueroa, J; Fletcher, O; Flyger, H; Galle, E; García-Closas, M; Giles, GG; Haeberle, L; Hall, P; Hillemanns, P; Hopper, JL; Jakubowska, A; John, EM; Jones, M; Khusnutdinova, E; Knight, JA; Kosma, V-M; Kristensen, V; Lee, A; Lindblom, A; Lubinski, J; Mannermaa, A; Margolin, S; Meindl, A; Milne, RL; Muranen, TA; Newcomb, PA; Offit, K; Park-Simon, T-W; Peto, J; Pharoah, PDP; Robson, M; Rudolph, A; Sawyer, EJ; Schmutzler, RK; Seynaeve, C; Soens, J; Southey, MC; Spurdle, AB; Surowy, H; Swerdlow, A; Tollenaar, RAEM; Tomlinson, I; Trentham-Dietz, A; Vachon, C; Wang, Q; Whittemore, AS; Ziogas, A; van der Kolk, L; Nevanlinna, H; Dörk, T; Bojesen, S; Easton, DF (2016-08-10)
    PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its ...
  • Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer. 

    Painter, JN; O'Mara, TA; Marquart, L; Webb, PM; Attia, J; Medland, SE; Cheng, T; Dennis, J; Holliday, EG; McEvoy, M; Scott, RJ; Ahmed, S; Healey, CS; Shah, M; Gorman, M; Martin, L; Hodgson, SV; Beckmann, MW; Ekici, AB; Fasching, PA; Hein, A; Rübner, M; Czene, K; Darabi, H; Hall, P; Li, J; Dörk, T; Dürst, M; Hillemanns, P; Runnebaum, IB; Amant, F; Annibali, D; Depreeuw, J; Lambrechts, D; Neven, P; Cunningham, JM; Dowdy, SC; Goode, EL; Fridley, BL; Winham, SJ; Njølstad, TS; Salvesen, HB; Trovik, J; Werner, HMJ; Ashton, KA; Otton, G; Proietto, A; Mints, M; Tham, E; Bolla, MK; Michailidou, K; Wang, Q; Tyrer, JP; Hopper, JL; Peto, J; Swerdlow, AJ; Burwinkel, B; Brenner, H; Meindl, A; Brauch, H; Lindblom, A; Chang-Claude, J; Couch, FJ; Giles, GG; Kristensen, VN; Cox, A; Pharoah, PDP; Tomlinson, I; Dunning, AM; Easton, DF; Thompson, DJ; Spurdle, AB; AOCS Group; for RENDOCAS; National Study of Endometrial Cancer Genetics Group (NSECG); Australian National Endometrial Cancer Study Group (ANECS)
    BACKGROUND: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, ...
  • Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain 

    Kijewska, M; Viski, C; Turrell, F; Fitzpatrick, A; van Weverwijk, A; Gao, Q; Iravani, M; Isacke, CM

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