Recent submissions
Now showing items 1-20 of 4705
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The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.
(WILEY, 2024-06-05)OBJECTIVES: To report the long-term outcomes from a longitudinal psychosocial study that forms part of the 'Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic ... -
Deep Learning for Automatic Segmentation, Treatment Planning and MRI Quantitative Analysis of Cervical Cancer
(Institute of Cancer Research (University Of London), 2024-07-25)Cervical cancer is a threatening global health concern for women, typically treated with radiation therapy (RT) in advanced stages, traditionally planned using computed tomography (CT) scans. However, advancements in medical ... -
Mass spectrometry strategies to understand treatment effects and heterogeneity in soft tissue sarcomas
(Institute of Cancer Research (University Of London), 2024-07-25)Soft Tissue sarcoma are rare and heterogenous mesenchymal malignancies. Optimal disease management in STS is surgical excision as the primary treatment modality. Despite negative surgical margins, ~50% of patients relapse. ... -
Melanoma cell morphogenesis in 3D environments
(Institute of Cancer Research (University Of London), 2024-07-25)During metastasis cancer cells invade tissues with diverse rigidities through dynamic changes in their cell shape. Most of our understanding of cancer cells shape determination comes from 2D studies on extremely stiff ... -
A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics.
(NATURE PORTFOLIO, 2024-07-03)Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin-stained tumor slides for precision oncology. We present ENLIGHT-DeepPT, an indirect two-step approach consisting of (1) DeepPT, a ... -
Predictability of B cell clonal persistence and immunosurveillance in breast cancer.
(NATURE PORTFOLIO, 2024-05-01)B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance ... -
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
(ELSEVIER, 2024-01-01) -
Using Mendelian Randomisation to search for modifiable risk factors influencing the development of clonal haematopoiesis.
(SPRINGERNATURE, 2024-07-16) -
Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program.
(NATURE PORTFOLIO, 2024-04-24)Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) ... -
Identification of genes that promote PI3K pathway activation and prostate tumour formation.
(SPRINGERNATURE, 2024-06-10)We have performed a functional in vivo mutagenesis screen to identify genes that, when altered, cooperate with a heterozygous Pten mutation to promote prostate tumour formation. Two genes, Bzw2 and Eif5a2, which have been ... -
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design
(NATURE PORTFOLIO, 2024-03-13) -
Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study.
(ELSEVIER, 2024-05-01)BACKGROUND: This study investigates the associations between air pollution and colorectal cancer (CRC) risk and survival from an epigenomic perspective. METHODS: Using a newly developed Air Pollutants Exposure Score (APES), ... -
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
(NATURE PORTFOLIO, 2024-04-26)Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought ... -
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
(NATURE PORTFOLIO, 2023-10-02)Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data ... -
Risks of second primary cancers among 584,965 female and male breast cancer survivors in England: a 25-year retrospective cohort study.
(ELSEVIER, 2024-05-01)BACKGROUND: Second primary cancers (SPCs) after breast cancer (BC) present an increasing public health burden, with little existing research on socio-demographic, tumour, and treatment effects. We addressed this in the ... -
Longitudinal Assessment of Tumor-Infiltrating Lymphocytes in Primary Breast Cancer Following Neoadjuvant Radiation Therapy.
(Elsevier BV, 2024-04-26)PURPOSE: Tumor-infiltrating lymphocytes (TILs) have prognostic significance in several cancers, including breast cancer. Despite interest in combining radiation therapy with immunotherapy, little is known about the effect ... -
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.
(NATURE PORTFOLIO, 2024-06-01)Acute myeloid leukemia (AML) is a largely incurable disease, for which new treatments are urgently needed. While leukemogenesis occurs in the hypoxic bone marrow, the therapeutic tractability of the hypoxia-inducible factor ... -
Society for Immunotherapy of Cancer (SITC) recommendations on intratumoral immunotherapy clinical trials (IICT): from premalignant to metastatic disease.
(BMJ PUBLISHING GROUP, 2024-04-18)BACKGROUND: Intratumorally delivered immunotherapies have the potential to favorably alter the local tumor microenvironment and may stimulate systemic host immunity, offering an alternative or adjunct to other local and ... -
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer.
(AMER ASSOC CANCER RESEARCH, 2024-07-15)Oncogenic KRAS impairs antitumor immune responses. As effective strategies to combine KRAS inhibitors and immunotherapies have so far proven elusive, a better understanding of the mechanisms by which oncogenic KRAS drives ...