Now showing items 1-3 of 3

    • SOX11 promotes invasive growth and ductal carcinoma in situ progression. 

      Oliemuller, E; Kogata, N; Bland, P; Kriplani, D; Daley, F; Haider, S; Shah, V; Sawyer, EJ; Howard, BA (2017-10)
      Here, we show that SOX11, an embryonic mammary marker that is normally silent in postnatal breast cells, is expressed in many oestrogen receptor-negative preinvasive ductal carcinoma in situ (DCIS) lesions. Mature mammary ...
    • A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells. 

      Domenici, G; Aurrekoetxea-Rodríguez, I; Simões, BM; Rábano, M; Lee, SY; Millán, JS; Comaills, V; Oliemuller, E; López-Ruiz, JA; Zabalza, I; Howard, BA; Kypta, RM; Vivanco, MD (2019-04)
      Increased cancer stem cell content during development of resistance to tamoxifen in breast cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling. Here, we show that Sox2 increases and ...
    • Sox9 regulates cell state and activity of embryonic mouse mammary progenitor cells. 

      Kogata, N; Bland, P; Tsang, M; Oliemuller, E; Lowe, A; Howard, BA (2018-01)
      Embryonic mammary cells are a unique population comprised of undifferentiated, highly plastic progenitor cells that create normal mammary tissues. The mammary gland continues to develop after birth from descendants of ...