Now showing items 1-3 of 3

    • Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. 

      Feltham, R; Jamal, K; Tenev, T; Liccardi, G; Jaco, I; Domingues, CM; Morris, O; John, SW; Annibaldi, A; Widya, M; Kearney, CJ; Clancy, D; Elliott, PR; Glatter, T; Qiao, Q; Thompson, AJ; Nesvizhskii, A; Schmidt, A; Komander, D; Wu, H; Martin, S; Meier, P (2018-04-10)
      Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show that the E3 ubiquitin ...
    • Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense. 

      Morris, O; Liu, X; Domingues, C; Runchel, C; Chai, A; Basith, S; Tenev, T; Chen, H; Choi, S; Pennetta, G; Buchon, N; Meier, P (2016-09)
      Pattern recognition receptors are activated following infection and trigger transcriptional programs important for host defense. Tight regulation of NF-κB activation is critical to avoid detrimental and misbalanced responses. ...
    • The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. 

      Orme, MH; Liccardi, G; Moderau, N; Feltham, R; Wicky-John, S; Tenev, T; Aram, L; Wilson, R; Bianchi, K; Morris, O; Monteiro Domingues, C; Robertson, D; Tare, M; Wepf, A; Williams, D; Bergmann, A; Gstaiger, M; Arama, E; Ribeiro, PS; Meier, P (2016-01)
      Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under non-apoptotic conditions and process ...