Browsing by author "Lundberg, Arian"

Now showing items 1-6 of 6

    • The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. 

      Sjöström, M; Zhao, SG; Levy, S; Zhang, M; Ning, Y; et al. (AMER ASSOC CANCER RESEARCH, 2022-11-02)
      UNLABELLED: Analysis of DNA methylation is a valuable tool to understand disease progression and is increasingly being used to create diagnostic and prognostic clinical biomarkers. While conversion of cytosine to ...

    • The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer. 

      Lundberg, A; Zhang, M; Aggarwal, R; Li, H; Zhang, L; et al. (AMER ASSOC CANCER RESEARCH, 2023-08-15)
      UNLABELLED: Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)-targeted therapy selectively favor the ...

    • Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate Cancer. 

      Feng, E; Rydzewski, NR; Zhang, M; Lundberg, A; Bootsma, M; et al. (AMER ASSOC CANCER RESEARCH, 2022-12-15)
      PURPOSE: Although numerous biology-driven subtypes have been described previously in metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping based on gene expression has been less studied, ...

    • The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours. 

      Lundberg, A; Lindström, LS; Li, J; Harrell, JC; Darai-Ramqvist, E; et al. (BMC, 2019-02-28)
      BACKGROUND: Use of cyclin D1 (CCND1) gene amplification as a breast cancer biomarker has been hampered by conflicting assessments of the relationship between cyclin D1 protein levels and patient survival. Here, we aimed ...

    • A pan-cancer analysis of the frequency of DNA alterations across cell cycle activity levels. 

      Lundberg, A; Lindström, LS; Parker, JS; Löverli, E; Perou, CM; et al. (SPRINGERNATURE, 2020-08-06)
      Pan-cancer genomic analyses based on the magnitude of pathway activity are currently lacking. Focusing on the cell cycle, we examined the DNA mutations and chromosome arm-level aneuploidy within tumours with low, intermediate ...

    • Reclassifying tumour cell cycle activity in terms of its tissue of origin. 

      Lundberg, A; Yi, JJJ; Lindström, LS; Tobin, NP (NATURE PORTFOLIO, 2022-08-20)
      Genomic alterations resulting in loss of control over the cell cycle is a fundamental hallmark of human malignancies. Whilst pan-cancer studies have broadly assessed tumour genomics and their impact on oncogenic pathways, ...