Now showing items 1-3 of 3

    • Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. 

      Abubakar, M; Chang-Claude, J; Ali, HR; Chatterjee, N; Coulson, P; Daley, F; Blows, F; Benitez, J; Milne, RL; Brenner, H; Stegmaier, C; Mannermaa, A; Rudolph, A; Sinn, P; Couch, FJ; Devilee, P; Tollenaar, RAEM; Seynaeve, C; Figueroa, J; Lissowska, J; Hewitt, S; Hooning, MJ; Hollestelle, A; Foekens, R; Koppert, LB; Investigators, K; Bolla, MK; Wang, Q; Jones, ME; Schoemaker, MJ; Keeman, R; Easton, DF; Swerdlow, AJ; Sherman, ME; Schmidt, MK; Pharoah, PD; Garcia-Closas, M (2018-08-15)
      Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ ...
    • High-throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium. 

      Abubakar, M; Howat, WJ; Daley, F; Zabaglo, L; McDuffus, LA; Blows, F; Coulson, P; Raza Ali, H; Benitez, J; Milne, R; Brenner, H; Stegmaier, C; Mannermaa, A; Chang-Claude, J; Rudolph, A; Sinn, P; Couch, FJ; Tollenaar, RA; Devilee, P; Figueroa, J; Sherman, ME; Lissowska, J; Hewitt, S; Eccles, D; Hooning, MJ; Hollestelle, A; Wm Martens, J; Hm van Deurzen, C; Investigators, K; Bolla, MK; Wang, Q; Jones, M; Schoemaker, M; Broeks, A; van Leeuwen, FE; Van't Veer, L; Swerdlow, AJ; Orr, N; Dowsett, M; Easton, D; Schmidt, MK; Pharoah, PD; Garcia-Closas, M (2016-07)
      Automated methods are needed to facilitate high-throughput and reproducible scoring of Ki67 and other markers in breast cancer tissue microarrays (TMAs) in large-scale studies. To address this need, we developed an automated ...
    • Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups. 

      Abubakar, M; Orr, N; Daley, F; Coulson, P; Ali, HR; Blows, F; Benitez, J; Milne, R; Brenner, H; Stegmaier, C; Mannermaa, A; Chang-Claude, J; Rudolph, A; Sinn, P; Couch, FJ; Devilee, P; Tollenaar, RAEM; Seynaeve, C; Figueroa, J; Sherman, ME; Lissowska, J; Hewitt, S; Eccles, D; Hooning, MJ; Hollestelle, A; Martens, JWM; van Deurzen, CHM; Investigators, K; Bolla, MK; Wang, Q; Jones, M; Schoemaker, M; Wesseling, J; van Leeuwen, FE; Van 't Veer, L; Easton, D; Swerdlow, AJ; Dowsett, M; Pharoah, PD; Schmidt, MK; Garcia-Closas, M (2016-10-18)
      BACKGROUND: The value of KI67 in breast cancer prognostication has been questioned due to concerns on the analytical validity of visual KI67 assessment and methodological limitations of published studies. Here, we investigate ...