Browsing by author "Swerdlow, Anthony"
Now showing items 1-20 of 108
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A case-control study of risk of leukaemia in relation to mobile phone use.
Cooke, R; Laing, S; Swerdlow, AJ (NATURE PUBLISHING GROUP, 2010-11-23)BACKGROUND: Mobile phone use is now ubiquitous, and scientific reviews have recommended research into its relation to leukaemia risk, but no large studies have been conducted. METHODS: In a case-control study in South East ... -
A pooling project of studies participating in the National Cancer Institute Cohort Consortium.
Swerdlow, A; schoemaker, M; wright, LB; brook, MN; jones, ME -
A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.
Lu, Y; Beeghly-Fadiel, A; Wu, L; Guo, X; Li, B; et al. (AMER ASSOC CANCER RESEARCH, 2018-09-15)Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in ... -
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Wu, L; Shi, W; Long, J; Guo, X; Michailidou, K; et al. (NATURE PORTFOLIO, 2018-07-01)The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify ... -
Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE study.
Au, L; Fendler, A; Boos, LA; Byrnes, F; Shepherd, S; et al. (AMER ASSOC CANCER RESEARCH, 2020-03-01) -
Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.
Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; Jones, ME; et al. (WILEY, 2020-09-01)Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies ... -
Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
Schmidt, MK; Hogervorst, F; van Hien, R; Cornelissen, S; Broeks, A; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2016-08-10)PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its ... -
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.
Wyszynski, A; Hong, C-C; Lam, K; Michailidou, K; Lytle, C; et al. (OXFORD UNIV PRESS, 2016-09-01)Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify ... -
Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium.
Trabert, B; Poole, EM; White, E; Visvanathan, K; Adami, H-O; et al. (OXFORD UNIV PRESS INC, 2019-02-01)BACKGROUND: Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily ... -
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law, PJ; Timofeeva, M; Fernandez-Rozadilla, C; Broderick, P; Studd, J; et al. (NATURE PUBLISHING GROUP, 2019-05-14)Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that ... -
Association analysis identifies 65 new breast cancer risk loci.
Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; et al. (2017-11)Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ... -
Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.
Swerdlow, A; Schoemaker, M; Wright, L; Brook, M; Jones, M -
Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.
Premenopausal Breast Cancer Collaborative Group,; Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; et al. (AMER MEDICAL ASSOC, 2018-11-01)IMPORTANCE: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover ... -
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Hamdi, Y; Soucy, P; Adoue, V; Michailidou, K; Canisius, S; et al. (IMPACT JOURNALS LLC, 2016-12-06)There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory ... -
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Zhao, Z; Wen, W; Michailidou, K; Bolla, MK; Wang, Q; et al. (SPRINGER, 2016-05-01)PURPOSE: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. METHODS: We constructed a genetic ... -
Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.
Rambau, PF; Vierkant, RA; Intermaggio, MP; Kelemen, LE; Goodman, MT; et al. (WILEY, 2018-10-01)We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade ... -
Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.
Shu, X; Wu, L; Khankari, NK; Shu, X-O; Wang, TJ; et al. (OXFORD UNIV PRESS, 2019-06-01)BACKGROUND: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. ... -
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
Shimelis, H; Mesman, RLS; Von Nicolai, C; Ehlen, A; Guidugli, L; et al. (AMER ASSOC CANCER RESEARCH, 2017-06-01)Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between ... -
Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.
Nichols, HB; Schoemaker, MJ; Cai, J; Xu, J; Wright, LB; et al. (AMER COLL PHYSICIANS, 2018-12-11)BACKGROUND: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or ... -
Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors.
Cooke, R; Jones, ME; Cunningham, D; Falk, SJ; Gilson, D; et al. (NATURE PUBLISHING GROUP, 2013-06-11)BACKGROUND: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors ...