Now showing items 1-5 of 5

    • Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets. 

      Krastev, DB; Pettitt, SJ; Campbell, J; Song, F; Tanos, BE; Stoynov, SS; Ashworth, A; Lord, CJ (2018-05-22)
      Poly (ADP-ribose)ylation is a dynamic protein modification that regulates multiple cellular processes. Here, we describe a system for identifying and characterizing PARylation events that exploits the ability of a PBZ ...
    • Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors. 

      Wong, JP; Todd, JR; Finetti, MA; McCarthy, F; Broncel, M; Vyse, S; Luczynski, MT; Crosier, S; Ryall, KA; Holmes, K; Payne, LS; Daley, F; Wai, P; Jenks, A; Tanos, B; Tan, A-C; Natrajan, RC; Williamson, D; Huang, PH (2016-10)
      Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF ...
    • An emerging role for IQGAP1 in tight junction control. 

      Tanos, BE; Yeaman, C; Rodriguez-Boulan, E (2018-09)
      IQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to ...
    • A kinase-independent function of AKT promotes cancer cell survival. 

      Vivanco, I; Chen, ZC; Tanos, B; Oldrini, B; Hsieh, W-Y; Yannuzzi, N; Campos, C; Mellinghoff, IK (2014-12-31)
      The serine-threonine kinase AKT regulates proliferation and survival by phosphorylating a network of protein substrates. In this study, we describe a kinase-independent function of AKT. In cancer cells harboring gain-of-function ...
    • Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer. 

      Jenks, AD; Vyse, S; Wong, JP; Kostaras, E; Keller, D; Burgoyne, T; Shoemark, A; Tsalikis, A; de la Roche, M; Michaelis, M; Cinatl, J; Huang, PH; Tanos, BE (2018-06)
      Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer ...