Now showing items 1-5 of 5

    • Acute myeloid leukemia xenograft success prediction: Saving time. 

      Griessinger, E; Vargaftig, J; Horswell, S; Taussig, DC; Gribben, J; Bonnet, D (2018-03)
      Xenograft assay allows functional analysis of leukemia-initiating cells of acute myeloid leukemia primary samples. However, 40% of samples derived from patients with better outcomes fail to engraft in immunodeficient mouse ...
    • Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study. 

      Berthon, C; Raffoux, E; Thomas, X; Vey, N; Gomez-Roca, C; Yee, K; Taussig, DC; Rezai, K; Roumier, C; Herait, P; Kahatt, C; Quesnel, B; Michallet, M; Recher, C; Lokiec, F; Preudhomme, C; Dombret, H (2016-04)
      <h4>Background</h4>Bromodomain and extraterminal (BET) proteins are chromatin readers that preferentially affect the transcription of genes with super-enhancers, including oncogenes. BET proteins bind acetylated histone ...
    • Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function. 

      Ghazaly, EA; Miraki-Moud, F; Smith, P; Gnanaranjan, C; Koniali, L; Oke, A; Saied, MH; Petty, R; Matthews, J; Stronge, R; Joel, SP; Young, BD; Gribben, J; Taussig, DC (2020-04)
      Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate ...
    • Single cell analysis of clonal architecture in acute myeloid leukaemia. 

      Potter, N; Miraki-Moud, F; Ermini, L; Titley, I; Vijayaraghavan, G; Papaemmanuil, E; Campbell, P; Gribben, J; Taussig, D; Greaves, M (2019-05)
      We used single cell Q-PCR on a micro-fluidic platform (Fluidigm) to analyse clonal, genetic architecture and phylogeny in acute myeloid leukaemia (AML) using selected mutations. Ten cases of NPM1c mutant AML were screened ...
    • The use of unfixed bone marrow trephines for multicolour flow cytometry. 

      Morilla, R; Moss, K; Nikolova, V; Marquardt, K; Duke, S; Adamowska, K; Fuller, L; Taifoor, A; Johnson, N; Zeisig, A; Morilla, A; Atra, A; Taussig, DC (2018-02)
      An adequate bone marrow aspirate is essential for a rapid diagnosis of acute leukaemia by multicolour flow cytometry enabling the simultaneous assessment of multiple antigens on the cell surface as well as intracellular ...