Browsing by author "Pines, Jonathon"
Now showing items 1-6 of 6
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Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.
Yost, S; de Wolf, B; Hanks, S; Zachariou, A; Marcozzi, C; et al. (NATURE PORTFOLIO, 2017-07-01)Through exome sequencing, we identified six individuals with biallelic loss-of-function mutations in TRIP13. All six developed Wilms tumor. Constitutional mosaic aneuploidies, microcephaly, developmental delay and seizures, ... -
Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy.
Barbiero, M; Cirillo, L; Veerapathiran, S; Coates, C; Ruffilli, C; et al. (ROYAL SOC, 2022-06-29)Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address. This considerable ... -
Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.
Strauss, B; Harrison, A; Coelho, PA; Yata, K; Zernicka-Goetz, M; et al. (ROCKEFELLER UNIV PRESS, 2018-01-02)There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is ... -
Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint.
Jackman, M; Marcozzi, C; Barbiero, M; Pardo, M; Yu, L; et al. (ROCKEFELLER UNIV PRESS, 2020-06-01)How the cell rapidly and completely reorganizes its architecture when it divides is a problem that has fascinated researchers for almost 150 yr. We now know that the core regulatory machinery is highly conserved in eukaryotes, ... -
Delayed APC/C activation extends the first mitosis of mouse embryos.
Ajduk, A; Strauss, B; Pines, J; Zernicka-Goetz, M (Springer Science and Business Media LLC, 2017-08-29)The correct temporal regulation of mitosis underpins genomic stability because it ensures the alignment of chromosomes on the mitotic spindle that is required for their proper segregation to the two daughter cells. Crucially, ... -
The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
Di Fiore, B; Wurzenberger, C; Davey, NE; Pines, J (CELL PRESS, 2016-12-15)The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex ...