Browsing by author "Bhattacharya, Indrani"
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Can Interrogation of Tumour Characteristics Lead us to Safely Omit Adjuvant Radiotherapy in Patients with Early Breast Cancer?
Bhattacharya, IS; Kirby, AM; Bliss, JM; Coles, CE (ELSEVIER SCIENCE LONDON, 2018-03-01)Adjuvant radiotherapy after breast-conserving surgery has been an important component of the standard of care for early breast cancer. Improvements in breast cancer care have resulted in a substantial reduction in local ... -
Can patient-reported outcomes be used instead of clinician-reported outcomes and photographs as primary endpoints of late normal tissue effects in breast radiotherapy trials? Results from the IMPORT LOW trial.
Bhattacharya, IS; Haviland, JS; Hopwood, P; Coles, CE; Yarnold, JR; et al. (ELSEVIER IRELAND LTD, 2019-05)BACKGROUND: In an era of low local relapse rates after adjuvant breast radiotherapy, risks of late normal-tissue effects (NTE) need to be balanced against risk of relapse. NTE are assessed using patient-reported outcome ... -
Clinical Trials From the Other Side: Lessons Learned by a Clinician Venturing Into a Clinical Trials Unit.
Bhattacharya, IS; Bliss, JM (ELSEVIER SCIENCE LONDON, 2019-07) -
Is breast seroma after tumour resection associated with patient-reported breast appearance change following radiotherapy? Results from the IMPORT HIGH (CRUK/06/003) trial.
Bhattacharya, IS; Haviland, JS; Perotti, C; Eaton, D; Gulliford, S; et al. (ELSEVIER IRELAND LTD, 2019-07)BACKGROUND: Seroma describes a collection of serous fluid within a cavity, occurring following surgery. Seroma is associated with normal tissue effects (NTE) following breast radiotherapy, as reported by clinicians and on ... -
Optimising trial methodologies to maximise trial efficiencies: a case study in breast cancer radiotherapy trials
Kirby, A; Bhattacharya, I (Institute of Cancer Research (University Of London), 2020-01-31)Background: In an era of falling local relapse rates, the risk-benefit ratio of adjuvant breast radiotherapy requires careful consideration, and the collection of normal tissue effect (NTE) data optimised. For patients at ... -
Partial breast radiotherapy after breast conservation surgery for early breast cancer: 5-year outcomes from the IMPORT LOW (CRUK/06/003) phase III randomised controlled trial
Coles, C; Griffin, C; Kirby, A; Titley, J; Agrawal, R; et al. (2017-05-15) -
Patient advocate involvement in the design and conduct of breast cancer clinical trials requiring the collection of multiple biopsies.
Batten, LM; Bhattacharya, IS; Moretti, L; Haviland, JS; Emson, MA; et al. (Springer Science and Business Media LLC, 2018-01-01)PLAIN ENGLISH SUMMARY: Breast cancer is a diverse and varied disease. Recent research has shown that the collection of multiple biopsies before surgery can help researchers determine how the cancer is responding to treatment ... -
Patient-Reported Outcomes Over 5 Years After Whole- or Partial-Breast Radiotherapy: Longitudinal Analysis of the IMPORT LOW (CRUK/06/003) Phase III Randomized Controlled Trial.
Bhattacharya, IS; Haviland, JS; Kirby, AM; Kirwan, CC; Hopwood, P; et al. (2019-02)Purpose IMPORT LOW demonstrated noninferiority of partial-breast and reduced-dose radiotherapy versus whole-breast radiotherapy for local relapse and similar or reduced toxicity at 5 years. Comprehensive patient-reported ... -
Patient-Reported Outcomes Over 5 Years After Whole- or Partial-Breast Radiotherapy: Longitudinal Analysis of the IMPORT LOW (CRUK/06/003) Phase III Randomized Controlled Trial.
Bhattacharya, IS; Haviland, JS; Kirby, AM; Kirwan, CC; Hopwood, P; et al. (AMER SOC CLINICAL ONCOLOGY, 2019-02-01)PURPOSE: IMPORT LOW demonstrated noninferiority of partial-breast and reduced-dose radiotherapy versus whole-breast radiotherapy for local relapse and similar or reduced toxicity at 5 years. Comprehensive patient-reported ... -
The Application and Feasibility of Using Routine Data Sources for Long-term Cancer Clinical Trial Follow-up.
Bhattacharya, IS; Morden, JP; Griffin, C; Snowdon, C; Brannan, R; et al. (2017-12)