Now showing items 1-9 of 9

    • AI delivers Michaelis constants as fuel for genome-scale metabolic models. 

      Antolin, AA; Cascante, M (2021-10-20)
      Michaelis constants (Km) are essential to predict the catalytic rate of enzymes, but are not widely available. A new study in PLOS Biology uses artificial intelligence (AI) to accurately predict Km on a proteome-wide scale, ...
    • canSAR: an updated cancer research and drug discovery knowledgebase. 

      Tym, JE; Mitsopoulos, C; Coker, EA; Razaz, P; Schierz, AC; Antolin, AA; Al-Lazikani, B (2016-01)
      canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, ...
    • canSAR: update to the cancer translational research and drug discovery knowledgebase. 

      Coker, EA; Mitsopoulos, C; Tym, JE; Komianou, A; Kannas, C; Di Micco, P; Villasclaras Fernandez, E; Ozer, B; Antolin, AA; Workman, P; Al-Lazikani, B (2019-01)
      canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug ...
    • Dual Inhibitors of PARPs and ROCKs. 

      Antolín, AA; Mestres, J (2018-10-05)
      Recent network and system biology analyses suggest that most complex diseases are regulated by robust and highly interconnected pathways that could be better modulated by small molecules binding to multiple biological ...
    • Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale. 

      Sandhu, D; Antolin, AA; Cox, AR; Jones, AM (2021-07-30)
      Aims The aim of this study was to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) between four approved PARP inhibitors (PARPi).Methods The Medicines and Healthcare ...
    • Objective, Quantitative, Data-Driven Assessment of Chemical Probes. 

      Antolin, AA; Tym, JE; Komianou, A; Collins, I; Workman, P; Al-Lazikani, B (2018-02)
      Chemical probes are essential tools for understanding biological systems and for target validation, yet selecting probes for biomedical research is rarely based on objective assessment of all potential compounds. Here, we ...
    • Polypharmacology in Precision Oncology: Current Applications and Future Prospects. 

      Antolin, AA; Workman, P; Mestres, J; Al-Lazikani, B (2016-01)
      Over the past decade, a more comprehensive, large-scale approach to studying cancer genetics and biology has revealed the challenges of tumor heterogeneity, adaption, evolution and drug resistance, while systems-based ...
    • Public resources for chemical probes: the journey so far and the road ahead. 

      Antolin, AA; Workman, P; Al-Lazikani, B (2019-11-28)
      High-quality small molecule chemical probes are extremely valuable for biological research and target validation. However, frequent use of flawed small-molecule inhibitors produces misleading results and diminishes the ...
    • The kinase polypharmacology landscape of clinical PARP inhibitors. 

      Antolin, AA; Ameratunga, M; Banerji, U; Clarke, PA; Workman, P; Al-Lazikani, B (2020-02-17)
      Polypharmacology plays an important role in defining response and adverse effects of drugs. For some mechanisms, experimentally mapping polypharmacology is commonplace, although this is typically done within the same protein ...