Browsing by author "Sheehan, Beshara"

Now showing items 1-4 of 4

    • HER3 Is an Actionable Target in Advanced Prostate Cancer. 

      Gil, V; Miranda, S; Riisnaes, R; Gurel, B; D'Ambrosio, M; et al. (AMER ASSOC CANCER RESEARCH, 2021-12-15)
      It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate cancer has been ineffective clinically. However, we show here that ...

    • Prostate specific membrane antigen and DNA damage repair in advanced prostate cancer 

      Sheehan, B (Institute of Cancer Research (University Of London), 2022-03-31)
      Identification and implementation of novel therapeutic strategies for advanced prostate cancer (PCa) remains an urgent, unmet clinical need. Prostate Specific Membrane Antigen (PSMA), a PCa biomarker, is currently being ...

    • Prostate-specific Membrane Antigen Heterogeneity and DNA Repair Defects in Prostate Cancer. 

      Paschalis, A; Sheehan, B; Riisnaes, R; Rodrigues, DN; Gurel, B; et al. (ELSEVIER, 2019-10-01)
      BACKGROUND: Prostate-specific membrane antigen (PSMA; folate hydrolase) prostate cancer (PC) expression has theranostic utility. OBJECTIVE: To elucidate PC PSMA expression and associate this with defective DNA damage repair ...

    • RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease. 

      Mandigo, AC; Yuan, W; Xu, K; Gallagher, P; Pang, A; et al. (AMER ASSOC CANCER RESEARCH, 2021-09-01)
      Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biological networks that drive cancer progression, although mechanistic insight has been largely limited to the impact of RB loss ...