Browsing by author "Maley, Carlo"
Now showing items 1-4 of 4
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Cancer across the tree of life: cooperation and cheating in multicellularity
(2015-07)Multicellularity is characterized by cooperation among cells for the development, maintenance and reproduction of the multicellular organism. Cancer can be viewed as cheating within this cooperative multicellular system. ... -
Modeling the Subclonal Evolution of Cancer Cell Populations
(2018-02)Increasing evidence shows that tumor clonal architectures are often the consequence of a complex branching process, yet little is known about the expected dynamics and extent to which these divergent subclonal expansions ... -
Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
(2017-02)Evolution by natural selection is the conceptual foundation for nearly every branch of biology and increasingly also for biomedicine and medical research. In cancer biology, evolution explains how populations of cells in ... -
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
(NATURE PUBLISHING GROUP, 2016-01)Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the bioinformatics tools ‘expanding ploidy and allele frequency on nested subpopulations’ (EXPANDS) and PyClone to detect ...
