Browsing by author "Cooper, Colin"
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Applications of microarray technology in breast cancer research
Cooper, CS (BIOMED CENTRAL LTD, 2001)Microarrays provide a versatile platform for utilizing information from the Human Genome Project to benefit human health. This article reviews the ways in which microarray technology may be used in breast cancer research. ... -
Concepts of epigenetics in prostate cancer development
Cooper, CS; Foster, CS (NATURE PUBLISHING GROUP, 2009-01-22)Substantial evidence now supports the view that epigenetic changes have a role in the development of human prostate cancer. Analyses of the patterns of epigenetic alteration are providing important insights into the origin ... -
Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study
Berney, DM; Gopalan, A; Kudahetti, S; Fisher, G; Ambroisine, L; et al. (NATURE PUBLISHING GROUP, 2009-03-17)Treatment decisions after diagnosis of clinically localised prostate cancer are difficult due to variability in tumour behaviour. We therefore examined one of the most promising biomarkers in prostate cancer, Ki-67, in a ... -
Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer
Ahmad, I; Singh, LB; Yang, ZH; Kalna, G; Fleming, J; et al. (NATURE PUBLISHING GROUP, 2013-01-15)Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)-extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate ... -
siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer
Bee, A; Brewer, D; Beesley, C; Dodson, A; Forootan, S; et al. (PUBLIC LIBRARY SCIENCE, 2011-07-22)We provide novel functional data that posttranscriptional silencing of gene RPL19 using RNAi not only abrogates the malignant phenotype of PC-3M prostate cancer cells but is selective with respect to transcription and ...