Now showing items 1-10 of 10

    • DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization 

      Reinhardt, HC; Hasskamp, P; Schmedding, I; Morandell, S; van Vugt, MATM; Wang, X; Linding, R; Ong, S-E; Weaver, D; Carr, SA; Yaffe, MB (CELL PRESS, 2010-10-08)
      Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the ...
    • Dynamic modularity in protein interaction networks predicts breast cancer outcome 

      Taylor, IW; Linding, R; Warde-Farley, D; Liu, Y; Pesquita, C; Faria, D; Bull, S; Pawson, T; Morris, Q; Wrana, JL (NATURE PUBLISHING GROUP, 2009-02)
      Changes in the biochemical wiring of oncogenic cells drives phenotypic transformations that directly affect disease outcome. Here we examine the dynamic structure of the human protein interaction network (interactome) to ...
    • ELM: the status of the 2010 eukaryotic linear motif resource. 

      Gould, CM; Diella, F; Via, A; Puntervoll, P; Gemünd, C; Chabanis-Davidson, S; Michael, S; Sayadi, A; Bryne, JC; Chica, C; Seiler, M; Davey, NE; Haslam, N; Weatheritt, RJ; Budd, A; Hughes, T; Pas, J; Rychlewski, L; Travé, G; Aasland, R; Helmer-Citterich, M; Linding, R; Gibson, TJ (2010-01)
      Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. ...
    • Experimental and computational tools useful for (re)construction of dynamic kinase-substrate networks 

      Tan, CSH; Linding, R (WILEY-BLACKWELL, 2009-12)
      The explosion of site- and context-specific in vivo phosphorylation events presents a potentially rich source of biological knowledge and calls for novel data analysis and modeling paradigms. Perhaps the most immediate ...
    • A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint 

      van Vugt, MATM; Gardino, AK; Linding, R; Ostheimer, GJ; Reinhardt, HC; Ong, S-E; Tan, CS; Miao, H; Keezer, SM; Li, J; Pawson, T; Lewis, TA; Carr, SA; Smerdon, SJ; Brummelkamp, TR; Yaffe, MB (PUBLIC LIBRARY SCIENCE, 2010-01)
      DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While ...
    • Network medicine 

      Pawson, T; Linding, R (Wiley-Blackwell, 2008-02-20)
      To more effectively target complex diseases like cancer, diabetes and schizophrenia, we may need to rethink our strategies for drug development and the selection of molecular targets for pharmacological treatments. Here, ...
    • Network-based drugs and biomarkers. 

      Erler, JT; Linding, R (2010-01)
      The structure and dynamics of protein signalling networks governs cell decision processes and the formation of tissue boundaries. Complex diseases such as cancer and diabetes are diseases of such networks. Therefore ...
    • NetworKIN: a resource for exploring cellular phosphorylation networks 

      Linding, R; Jensen, LJ; Pasculescu, A; Olhovsky, M; Colwill, K; Bork, P; Yaffe, MB; Pawson, T (OXFORD UNIV PRESS, 2008-01)
      Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically ...
    • Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells 

      Van Hoof, D; Munoz, J; Braam, SR; Pinkse, MWH; Linding, R; Heck, AJR; Mummery, CL; Krijgsveld, J (CELL PRESS, 2009-08-07)
      Pluripotent stem cells, self-renew indefinitely and possess characteristic protein-protein networks that remodel during differentiation. How this occurs is poorly understood. Using quantitative mass spectrometry, we analyzed ...
    • Positive Selection of Tyrosine Loss in Metazoan Evolution 

      Tan, CSH; Pasculescu, A; Lim, WA; Pawson, T; Bader, GD; Linding, R (AMER ASSOC ADVANCEMENT SCIENCE, 2009-09-25)
      John Nash showed that within a complex system, individuals are best off if they make the best decision that they can, taking into account the decisions of the other individuals. Here, we investigate whether similar principles ...