Browsing by author "Sialana, Fernando Jr"
Now showing items 1-8 of 8
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iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
Bouguenina, H; Nicolaou, S; Le Bihan, Y-V; Bowling, EA; Calderon, C; et al. (CELL PRESS, 2023-07-21)To address the limitation associated with degron based systems, we have developed iTAG, a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses the limitations of both PROTAC and previous ... -
The Lack of Dopamine Transporter Is Associated With Conditional Associative Learning Impairments and Striatal Proteomic Changes.
Savchenko, A; Müller, C; Lubec, J; Leo, D; Korz, V; et al. (FRONTIERS MEDIA SA, 2022-03-18)Dopamine (DA) is critically involved in different functions of the central nervous system (CNS) including control of voluntary movement, affect, reward, sleep, and cognition. One of the key components of DA neurotransmission ... -
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Haq, N; Schmidt-Hieber, C; Sialana, FJ; Ciani, L; Heller, JP; et al. (PUBLIC LIBRARY SCIENCE, 2019-09-01)Bardet-Biedl syndrome (BBS), a ciliopathy, is a rare genetic condition characterised by retinal degeneration, obesity, kidney failure, and cognitive impairment. In spite of progress made in our general understanding of BBS ... -
A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids.
Narzt, M-S; Nagelreiter, I-M; Oskolkova, O; Bochkov, VN; Latreille, J; et al. (ELSEVIER, 2019-01-01)Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon ... -
Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.
López de la Oliva, AR; Campos-Sandoval, JA; Gómez-García, MC; Cardona, C; Martín-Rufián, M; et al. (NATURE PUBLISHING GROUP, 2020-02-10)Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have been consistently ... -
Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum.
Sialana, FJ; Wang, A-L; Fazari, B; Kristofova, M; Smidak, R; et al. (FRONTIERS MEDIA SA, 2018-02-06)Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat overexpressing non-mutant human DISC1, ... -
Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat.
Smidak, R; Sialana, FJ; Kristofova, M; Stojanovic, T; Rajcic, D; et al. (FRONTIERS MEDIA SA, 2017-11-23)Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic ... -
SimPLIT: Simplified Sample Preparation for Large-Scale Isobaric Tagging Proteomics.
Sialana, FJ; Roumeliotis, TI; Bouguenina, H; Chan Wah Hak, L; Wang, H; et al. (AMER CHEMICAL SOC, 2022-08-05)Large scale proteomic profiling of cell lines can reveal molecular signatures attributed to variable genotypes or induced perturbations, enabling proteogenomic associations and elucidation of pharmacological mechanisms of ...