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    • Structural basis for the inhibition of cGAS by nucleosomes. 

      Kujirai, T; Zierhut, C; Takizawa, Y; Kim, R; Negishi, L; Uruma, N; Hirai, S; Funabiki, H; Kurumizaka, H (2020-10)
      The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and apoptosis. Organization of host DNA into nucleosomes was ...