Browsing by author "Evans, Ian"
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Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Mahmoud, M; Evans, I; Wisniewski, L; Tam, Y; Walsh, C; et al. (OXFORD UNIV PRESS, 2022-06-29)AIMS: The adapter protein p130Cas, encoded by the Bcar1 gene, is a key regulator of cell movement, adhesion, and cell cycle control in diverse cell types. Bcar1 constitutive knockout mice are embryonic lethal by embryonic ... -
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas.
Gribben, C; Lambert, C; Messal, HA; Hubber, E-L; Rackham, C; et al. (CELL PRESS, 2021-11-04)Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ... -
Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling.
Frolov, A; Evans, IM; Li, N; Sidlauskas, K; Paliashvili, K; et al. (NATURE PORTFOLIO, 2016-06-13)Imatinib was the first targeted tyrosine kinase inhibitor to be approved for clinical use, and remains first-line therapy for Philadelphia chromosome (Ph+)-positive chronic myelogenous leukaemia. We show that treatment of ... -
Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.
Li, N; Zhang, Y; Sidlauskas, K; Ellis, M; Evans, I; et al. (NATURE PUBLISHING GROUP, 2018-08-02)To identify biomarkers for glioma growth, invasion and progression, we used a candidate gene approach in mouse models with two complementary brain tumour phenotypes, developing either slow-growing, diffusely infiltrating ... -
PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway.
Li, H; Wang, C; Lan, L; Wu, W; Evans, I; et al. (FRONTIERS MEDIA SA, 2021-08-23)Oxaliplatin (OXA) resistance in the treatment of different types of cancer is an important and complex problem. The culture of tumor organoids derived from gastric cancer can help us to provide a deeper understanding of ... -
USP7 controls NGN3 stability and pancreatic endocrine lineage development.
Manea, T; Nelson, JK; Garrone, CM; Hansson, K; Evans, I; et al. (NATURE PORTFOLIO, 2023-04-28)Understanding the factors and mechanisms involved in beta-cell development will guide therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) is the key transcription factor that marks ... -
Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis.
Evans, IM; Kennedy, SA; Paliashvili, K; Santra, T; Yamaji, M; et al. (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-02-01)p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells ...