Browsing by author "Turgeon, Marc-Olivier"

Now showing items 1-4 of 4

    • Asparagine bioavailability governs metastasis in a model of breast cancer. 

      Knott, SRV; Wagenblast, E; Khan, S; Kim, SY; Soto, M; et al. (NATURE PORTFOLIO, 2018-02-15)
      Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary ...

    • BRCA1 loss-of-function triggers metabolic vulnerability to glutamine deprivation 

      Poulogiannis, G; Turgeon, M-O (Institute of Cancer Research (University Of London), 2021-01-31)
      Germline and somatic mutations of BRCA1 are associated with cancer initiation and progression. Although the role of BRCA1 is clearly defined in DNA-repair pathways, alternative functions of BRCA1 still remain obscure. Here, ...

    • Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance. 

      Martin, L-A; Ribas, R; Simigdala, N; Schuster, E; Pancholi, S; et al. (NATURE PORTFOLIO, 2017-11-30)
      Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show increased prevalence in the metastatic, ...

    • DNA Damage, Repair, and Cancer Metabolism. 

      Turgeon, M-O; Perry, NJS; Poulogiannis, G (FRONTIERS MEDIA SA, 2018-02-05)
      Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored. In this review, we examine ...