Browsing by author "Helin, Kristian"
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An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions.
Radzisheuskaya, A; Peña-Rømer, I; Lorenzini, E; Koche, R; Zhan, Y; et al. (WILEY, 2023-12-11)Efficient treatment of acute myeloid leukemia (AML) patients remains a challenge despite recent therapeutic advances. Here, using a CRISPRi screen targeting chromatin factors, we identified the nucleosome-remodeling factor ... -
Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1.
Sun, Z; Lin, Y; Islam, MT; Koche, R; Hedehus, L; et al. (CELL PRESS, 2023-07-20)Nuclear receptor-binding SET-domain protein 1 (NSD1), a methyltransferase that catalyzes H3K36me2, is essential for mammalian development and is frequently dysregulated in diseases, including Sotos syndrome. Despite the ... -
An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate.
Hansen, SL; Larsen, HL; Pikkupeura, LM; Maciag, G; Guiu, J; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2023-07-14)Generation of functionally mature organs requires exquisite control of transcriptional programs governing cell state transitions during development. Despite advances in understanding the behavior of adult intestinal stem ...