Browsing by author "Erler, Janine Terra"
Now showing items 1-2 of 2
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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
Cox, TR; Rumney, RMH; Schoof, EM; Perryman, L; Hoye, AM; et al. (NATURE PUBLISHING GROUP, 2015-06-04)Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ... -
Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling
Barker, HE; Bird, D; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-11-01)Cancer-associated fibroblasts enhance cancer progression when activated by tumor cells through mechanisms not yet fully understood. Blocking mammary tumor cell-derived lysyl oxidase-like 2 (LOXL2) significantly inhibited ...