Now showing items 1-2 of 2

    • The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase 

      Cox, TR; Rumney, RMH; Schoof, EM; Perryman, L; Hoye, AM; et al. (NATURE PUBLISHING GROUP, 2015-06-04)
      Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ...
    • Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling 

      Barker, HE; Bird, D; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-11-01)
      Cancer-associated fibroblasts enhance cancer progression when activated by tumor cells through mechanisms not yet fully understood. Blocking mammary tumor cell-derived lysyl oxidase-like 2 (LOXL2) significantly inhibited ...