Now showing items 2190-2209 of 3129

    • Plasticity revisited 

      Joshi, CV; Enver, T (2002)
      Despite some recent setbacks, it remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated. This is ...
    • Platinum-Fluoropyrimidine and Paclitaxel-Based Chemotherapy in the Treatment of Advanced Anal Cancer Patients. 

      Sclafani, F; Morano, F; Cunningham, D; Baratelli, C; Kalaitzaki, E; Watkins, D; Starling, N; Chau, I; Rao, S (2017-04)
      BACKGROUND: Although treatment of localized anal cancer (AC) is well established, very little evidence is available to inform the management of advanced tumors, and the prognosis of these patients remains poor. We have ...
    • PLCgamma1 is essential for early events in integrin signalling required for cell motility. 

      Jones, NP; Peak, J; Brader, S; Eccles, SA; Katan, M (2005-06)
      Cell motility is a critical event in many processes and is underlined by complex signalling interactions. Although many components have been implicated in different forms of cell migration, identification of early key ...
    • Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. 

      Zuber, V; Marconett, CN; Shi, J; Hua, X; Wheeler, W; Yang, C; Song, L; Dale, AM; Laplana, M; Risch, A; Witoelar, A; Thompson, WK; Schork, AJ; Bettella, F; Wang, Y; Djurovic, S; Zhou, B; Borok, Z; van der Heijden, HF; de Graaf, J; Swinkels, D; Aben, KK; McKay, J; Hung, RJ; Bikeböller, H; Stevens, VL; Albanes, D; Caporaso, NE; Han, Y; Wei, Y; Panadero, MA; Mayordomo, JI; Christiani, DC; Kiemeney, L; Andreassen, OA; Houlston, R; Amos, CI; Chatterjee, N; Laird-Offringa, IA; Mills, IG; Landi, MT (2016-12)
      Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted ...
    • Pneumothorax from Subpleural Blebs-A New Association of Sotos Syndrome? 

      Tatton Brown, Katrina (2014-05)
      We describe two unrelated patients with molecularly confirmed Sotos syndrome with multiple subpleural blebs and pneumothorax. We propose this as a new association. Patient 1 is a 3-year-old boy with a 1.9Mb interstitial ...
    • A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation 

      Richards, MW; Leung, JWC; Roe, SM; Li, K; Chen, J; Bayliss, R (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2010-02-05)
      Mcph1 is mutated in autosomal recessive primary microcephaly and premature chromosome condensation (PCC) syndrome. Increased chromosome condensation is a common feature of cells isolated from patients afflicted with either ...
    • Point Mutations in a Hinge Linking the Small and Large Domains of β-Actin Result in Trapped Folding Intermediates Bound to Cytosolic Chaperonin CCT 

      McCormack, EA; Llorca, O; Carrascosa, JL; Valpuesta, J-M; Willison, KR (2001)
      The30-Å cryo-EM-derived structure of apo-CCT–α-actin shows actin opened up across its nucleotide-binding cleft and binding to either of two CCT subunit pairs, CCTβ–CCTδ or CCTϵ–CCTδ, in a similar 1:4 arrangement. The two ...
    • Polycythemia vera: analysis of DNA from blood granulocytes using comparative genomic hybridization 

      Gruszka-Westwood, Alicja (2001-05)
      Polycythemia vera: analysis of DNA from blood granulocytes using comparative genomic hybridization. Background and Objectives. The diagnosis of polycythemia vera (PV) is supported by the finding of an abnormal karyotype ...
    • Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. 

      Seibert, TM; Fan, CC; Wang, Y; Zuber, V; Karunamuni, R; Parsons, JK; Eeles, RA; Easton, DF; Kote-Jarai, Z; Al Olama, AA; Garcia, SB; Muir, K; Grönberg, H; Wiklund, F; Aly, M; Schleutker, J; Sipeky, C; Tammela, TL; Nordestgaard, BG; Nielsen, SF; Weischer, M; Bisbjerg, R; Røder, MA; Iversen, P; Key, TJ; Travis, RC; Neal, DE; Donovan, JL; Hamdy, FC; Pharoah, P; Pashayan, N; Khaw, K-T; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, L; Brenner, H; Cuk, K; Saum, K-U; Park, JY; Sellers, TA; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Clements, JA; Spurdle, A; Teixeira, MR; Paulo, P; Maia, S; Pandha, H; Michael, A; Kierzek, A; Karow, DS; Mills, IG; Andreassen, OA; Dale, AM; PRACTICAL Consortium* (2018-01-10)
      OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to ...
    • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. 

      Mavaddat, N; Michailidou, K; Dennis, J; Lush, M; Fachal, L; Lee, A; Tyrer, JP; Chen, T-H; Wang, Q; Bolla, MK; Yang, X; Adank, MA; Ahearn, T; Aittomäki, K; Allen, J; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arndt, V; Aronson, KJ; Auer, PL; Auvinen, P; Barrdahl, M; Beane Freeman, LE; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Bernstein, L; Blomqvist, C; Bogdanova, NV; Bojesen, SE; Bonanni, B; Børresen-Dale, A-L; Brauch, H; Bremer, M; Brenner, H; Brentnall, A; Brock, IW; Brooks-Wilson, A; Brucker, SY; Brüning, T; Burwinkel, B; Campa, D; Carter, BD; Castelao, JE; Chanock, SJ; Chlebowski, R; Christiansen, H; Clarke, CL; Collée, JM; Cordina-Duverger, E; Cornelissen, S; Couch, FJ; Cox, A; Cross, SS; Czene, K; Daly, MB; Devilee, P; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Durcan, L; Dwek, M; Eccles, DM; Ekici, AB; Eliassen, AH; Ellberg, C; Engel, C; Eriksson, M; Evans, DG; Fasching, PA; Figueroa, J; Fletcher, O; Flyger, H; Försti, A; Fritschi, L; Gabrielson, M; Gago-Dominguez, M; Gapstur, SM; García-Sáenz, JA; Gaudet, MM; Georgoulias, V; Giles, GG; Gilyazova, IR; Glendon, G; Goldberg, MS; Goldgar, DE; González-Neira, A; Grenaker Alnæs, GI; Grip, M; Gronwald, J; Grundy, A; Guénel, P; Haeberle, L; Hahnen, E; Haiman, CA; Håkansson, N; Hamann, U; Hankinson, SE; Harkness, EF; Hart, SN; He, W; Hein, A; Heyworth, J; Hillemanns, P; Hollestelle, A; Hooning, MJ; Hoover, RN; Hopper, JL; Howell, A; Huang, G; Humphreys, K; Hunter, DJ; Jakimovska, M; Jakubowska, A; Janni, W; John, EM; Johnson, N; Jones, ME; Jukkola-Vuorinen, A; Jung, A; Kaaks, R; Kaczmarek, K; Kataja, V; Keeman, R; Kerin, MJ; Khusnutdinova, E; Kiiski, JI; Knight, JA; Ko, Y-D; Kosma, V-M; Koutros, S; Kristensen, VN; Krüger, U; Kühl, T; Lambrechts, D; Le Marchand, L; Lee, E; Lejbkowicz, F; Lilyquist, J; Lindblom, A; Lindström, S; Lissowska, J; Lo, W-Y; Loibl, S; Long, J; Lubiński, J; Lux, MP; MacInnis, RJ; Maishman, T; Makalic, E; Maleva Kostovska, I; Mannermaa, A; Manoukian, S; Margolin, S; Martens, JWM; Martinez, ME; Mavroudis, D; McLean, C; Meindl, A; Menon, U; Middha, P; Miller, N; Moreno, F; Mulligan, AM; Mulot, C; Muñoz-Garzon, VM; Neuhausen, SL; Nevanlinna, H; Neven, P; Newman, WG; Nielsen, SF; Nordestgaard, BG; Norman, A; Offit, K; Olson, JE; Olsson, H; Orr, N; Pankratz, VS; Park-Simon, T-W; Perez, JIA; Pérez-Barrios, C; Peterlongo, P; Peto, J; Pinchev, M; Plaseska-Karanfilska, D; Polley, EC; Prentice, R; Presneau, N; Prokofyeva, D; Purrington, K; Pylkäs, K; Rack, B; Radice, P; Rau-Murthy, R; Rennert, G; Rennert, HS; Rhenius, V; Robson, M; Romero, A; Ruddy, KJ; Ruebner, M; Saloustros, E; Sandler, DP; Sawyer, EJ; Schmidt, DF; Schmutzler, RK; Schneeweiss, A; Schoemaker, MJ; Schumacher, F; Schürmann, P; Schwentner, L; Scott, C; Scott, RJ; Seynaeve, C; Shah, M; Sherman, ME; Shrubsole, MJ; Shu, X-O; Slager, S; Smeets, A; Sohn, C; Soucy, P; Southey, MC; Spinelli, JJ; Stegmaier, C; Stone, J; Swerdlow, AJ; Tamimi, RM; Tapper, WJ; Taylor, JA; Terry, MB; Thöne, K; Tollenaar, RAEM; Tomlinson, I; Truong, T; Tzardi, M; Ulmer, H-U; Untch, M; Vachon, CM; van Veen, EM; Vijai, J; Weinberg, CR; Wendt, C; Whittemore, AS; Wildiers, H; Willett, W; Winqvist, R; Wolk, A; Yang, XR; Yannoukakos, D; Zhang, Y; Zheng, W; Ziogas, A; ABCTB Investigators; kConFab/AOCS Investigators; NBCS Collaborators; Dunning, AM; Thompson, DJ; Chenevix-Trench, G; Chang-Claude, J; Schmidt, MK; Hall, P; Milne, RL; Pharoah, PDP; Antoniou, AC; Chatterjee, N; Kraft, P; García-Closas, M; Simard, J; Easton, DF (2019-01-03)
      Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen ...
    • Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids 

      Hardcastle, IR; Barber, AM; Marriott, JH; Jarman, M (2001)
      The efficient synthesis of a small library of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids is described via the fluoride mediated alkylation of 5,6,8-trifluoro-7-hydroxy-2-methyl-benzo[1,3]dioxin-4-one with a collection ...
    • Polymorphisms of DNA repair genes and risk of non-small cell lung cancer 

      Zienolddiny, S; Campa, D; Lind, H; Ryberg, D; Skaug, V; Stangeland, L; Phillips, DH; Canzian, F; Haugen, A (OXFORD UNIV PRESS, 2006-03)
      Lung cancer is a leading cause of cancer mortality with an inter-individual difference in susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA repair and replication may contribute to ...
    • Polypharmacology in Precision Oncology: Current Applications and Future Prospects. 

      Antolin, AA; Workman, P; Mestres, J; Al-Lazikani, B (2016-09-23)
      Over the past decade, a more comprehensive, large-scale approach to studying cancer genetics and biology has revealed the challenges of tumor heterogeneity, adaption, evolution and drug resistance, while systems-based ...
    • Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium. 

      Khankari, NK; Murff, HJ; Zeng, C; Wen, W; Eeles, RA; Easton, DF; Kote-Jarai, Z; Al Olama, AA; Benlloch, S; Muir, K; Giles, GG; Wiklund, F; Gronberg, H; Haiman, CA; Schleutker, J; Nordestgaard, BG; Travis, RC; Donovan, JL; Pashayan, N; Khaw, KT; Stanford, JL; Blot, WJ; Thibodeau, SN; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Brenner, H; Park, J; Kaneva, R; Batra, J; Teixeira, MR; Pandha, H; Zheng, W (2016-08-04)
      Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been inconsistent. ...
    • Pooled Systemic Efficacy and Safety Data from the Pivotal Phase II Studies (NP28673 and NP28761) of Alectinib in ALK-positive Non-Small Cell Lung Cancer. 

      Yang, JC-H; Ou, S-HI; De Petris, L; Gadgeel, S; Gandhi, L; Kim, D-W; Barlesi, F; Govindan, R; Dingemans, A-MC; Crino, L; Lena, H; Popat, S; Ahn, JS; Dansin, E; Golding, S; Bordogna, W; Balas, B; Morcos, PN; Zeaiter, A; Shaw, AT (2017-10)
      INTRODUCTION: Alectinib demonstrated clinical efficacy and an acceptable safety profile in two phase II studies (NP28761 and NP28673). Here we report the pooled efficacy and safety data after 15 and 18 months more follow-up ...
    • A pooling project of studies participating in the National Cancer Institute Cohort Consortium. 

      Swerdlow, A; schoemaker, M; wright, LB; brook, MN; jones, ME
    • Poor treatment outcomes with palliative gemcitabine and docetaxel chemotherapy in advanced and metastatic synovial sarcoma. 

      Pender, A; Davis, EJ; Chauhan, D; Messiou, C; Al-Muderis, O; Thway, K; Fisher, C; Zaidi, S; Miah, A; Judson, I; van der Graaf, W; Keedy, VL; Benson, C; Jones, RL (2018-08-20)
      The outcome for patients with unresectable or metastatic soft tissue sarcoma remains poor with few treatment options. Synovial sarcoma is a rare type of sarcoma, predominantly affecting adolescents and young adults. Following ...
    • Population screening for colorectal cancer: the implications of an ageing population 

      Macafee, DAL; Waller, M; Whynes, DK; Moss, S; Scholefield, JH (NATURE PUBLISHING GROUP, 2008-12-09)
      Population screening for colorectal cancer (CRC) has recently commenced in the United Kingdom supported by the evidence of a number of randomised trials and pilot studies. Certain factors are known to influence screening ...
    • The positive experience of screening quality among users of a cervical cancer detection center 

      Lazcano-Ponce, EC; Moss, S; Cruz-Valdez, A; de Ruiz, PA; Martinez-Leon, CJ; Casares-Queralt, S; Hernandez-Avila, M
      Background. Our objective was to determine the main factors associated with increased utilization of a cervical cancer screening program (CCSP) in a population with a high mortality rate due to cervical cancer. Methods. A ...
    • Positive selection of a gene family during the emergence of humans and African apes 

      Johnson, ME; Viggiano, L; Bailey, JA; Abdul-Rauf, M; Goodwin, G; Rocchi, M; Eichler, EE (NATURE PUBLISHING GROUP, 2001-10-04)
      Gene duplication followed by adaptive evolution is one of the primary forces for the emergence of new gene function(1). Here we describe the recent proliferation, transposition and selection of a 20-kilobase (kb) duplicated ...