Browsing by author "Brisken, Cathrin"
Now showing items 21-23 of 23
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Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!
Ronchi, C; Brisken, C (AMER ASSOC CANCER RESEARCH, 2023-03-01)The presurgical window of opportunity trial (WOT) MIPRA provides evidence that neoadjuvant treatment with the progesterone receptor (PR) antagonist mifepristone (RU486) may benefit patients with estrogen receptor-positive ... -
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression.
Gibson, SV; Tomas Bort, E; Rodríguez-Fernández, L; Allen, MD; Gomm, JJ; et al. (NATURE PORTFOLIO, 2023-03-02)Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. ... -
The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche.
Ataca, D; Aouad, P; Constantin, C; Laszlo, C; Beleut, M; et al. (NATURE PUBLISHING GROUP, 2020-03-26)Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important ...