Browsing by author "O'Connor, James Patrick"
Now showing items 21-32 of 32
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Oxygen Enhanced Optoacoustic Tomography (OE-OT) Reveals Vascular Dynamics in Murine Models of Prostate Cancer.
Tomaszewski, MR; Gonzalez, IQ; O'Connor, JP; Abeyakoon, O; Parker, GJ; et al. (IVYSPRING INT PUBL, 2017-01-01)Poor oxygenation of solid tumours has been linked with resistance to chemo- and radio-therapy and poor patient outcomes, hence non-invasive imaging of oxygen supply and demand in tumours could improve disease staging and ... -
Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models.
O'Connor, JPB; Boult, JKR; Jamin, Y; Babur, M; Finegan, KG; et al. (AMER ASSOC CANCER RESEARCH, 2015-11-19)There is a clinical need for noninvasive biomarkers of tumor hypoxia for prognostic and predictive studies, radiotherapy planning, and therapy monitoring. Oxygen-enhanced MRI (OE-MRI) is an emerging imaging technique for ... -
Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non-small Cell Lung Cancer.
Salem, A; Little, RA; Latif, A; Featherstone, AK; Babur, M; et al. (AMER ASSOC CANCER RESEARCH, 2019-07-01)PURPOSE: Hypoxia is associated with poor prognosis and is predictive of poor response to cancer treatments, including radiotherapy. Developing noninvasive biomarkers that both detect hypoxia prior to treatment and track ... -
Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer.
Jayson, GC; Zhou, C; Backen, A; Horsley, L; Marti-Marti, K; et al. (NATURE PUBLISHING GROUP, 2018-11-07)Oncological use of anti-angiogenic VEGF inhibitors has been limited by the lack of informative biomarkers. Previously we reported circulating Tie2 as a vascular response biomarker for bevacizumab-treated ovarian cancer ... -
Radiomic Features From Diffusion-Weighted MRI of Retroperitoneal Soft-Tissue Sarcomas Are Repeatable and Exhibit Change After Radiotherapy.
Thrussell, I; Winfield, JM; Orton, MR; Miah, AB; Zaidi, SH; et al. (FRONTIERS MEDIA SA, 2022-07-18)BACKGROUND: Size-based assessments are inaccurate indicators of tumor response in soft-tissue sarcoma (STS), motivating the requirement for new response imaging biomarkers for this rare and heterogeneous disease. In this ... -
Radiomics as a personalized medicine tool in lung cancer: Separating the hope from the hype.
Fornacon-Wood, I; Faivre-Finn, C; O'Connor, JPB; Price, GJ (ELSEVIER IRELAND LTD, 2020-08-01)Radiomics has become a popular image analysis method in the last few years. Its key hypothesis is that medical images harbor biological, prognostic and predictive information that is not revealed upon visual inspection. ... -
Reliability and prognostic value of radiomic features are highly dependent on choice of feature extraction platform.
Fornacon-Wood, I; Mistry, H; Ackermann, CJ; Blackhall, F; McPartlin, A; et al. (SPRINGER, 2020-11-01)OBJECTIVE: To investigate the effects of Image Biomarker Standardisation Initiative (IBSI) compliance, harmonisation of calculation settings and platform version on the statistical reliability of radiomic features and their ... -
Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems.
Waterton, JC; Hines, CDG; Hockings, PD; Laitinen, I; Ziemian, S; et al. (ELSEVIER SCIENCE INC, 2019-06-01)BACKGROUND: Many translational MR biomarkers derive from measurements of the water proton longitudinal relaxation rate R1, but evidence for between-site reproducibility of R1 in small-animal MRI is lacking. OBJECTIVE: To ... -
Rethinking the role of clinical imaging.
O'Connor, JP (ELIFE SCIENCES PUBLICATIONS LTD, 2017-09-06)Radiomics has the potential to improve the management of cancer patients, but further research is required before it can be adopted into routine clinical practice. -
Standardised lesion segmentation for imaging biomarker quantitation: a consensus recommendation from ESR and EORTC.
deSouza, NM; van der Lugt, A; Deroose, CM; Alberich-Bayarri, A; Bidaut, L; et al. (SPRINGER, 2022-10-04)BACKGROUND: Lesion/tissue segmentation on digital medical images enables biomarker extraction, image-guided therapy delivery, treatment response measurement, and training/validation for developing artificial intelligence ... -
Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome.
Salem, A; Asselin, M-C; Reymen, B; Jackson, A; Lambin, P; et al. (OXFORD UNIV PRESS INC, 2018-01-01)Oxygen deprivation (hypoxia) in non-small cell lung cancer (NSCLC) is an important factor in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target, particularly in the context of radiotherapy, ... -
Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR).
deSouza, NM; Achten, E; Alberich-Bayarri, A; Bamberg, F; Boellaard, R; et al. (SPRINGER, 2019-08-29)Observer-driven pattern recognition is the standard for interpretation of medical images. To achieve global parity in interpretation, semi-quantitative scoring systems have been developed based on observer assessments; ...