Browsing by author "Eeles, Rosalind"
Now showing items 81-100 of 168
-
Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants.
Wu, L; Wang, J; Cai, Q; Cavazos, TB; Emami, NC; et al. (AMER ASSOC CANCER RESEARCH, 2019-07-01)Genome-wide association study-identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain ... -
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Milne, RL; Kuchenbaecker, KB; Michailidou, K; Beesley, J; Kar, S; et al. (NATURE PORTFOLIO, 2017-12-01)Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative ... -
Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer.
Hansen, EB; Karlsson, Q; Merson, S; Wakerell, S; Rageevakumar, R; et al. (NATURE PORTFOLIO, 2023-11-06)The clinical importance of germline variants in DNA repair genes (DRGs) is becoming increasingly recognized, but their impact on advanced prostate cancer prognosis remains unclear. A cohort of 221 newly diagnosed metastatic ... -
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
Pritchard, CC; Mateo, J; Walsh, MF; De Sarkar, N; Abida, W; et al. (MASSACHUSETTS MEDICAL SOC, 2016-08-04)BACKGROUND: Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized ... -
Interim Results from the IMPACT Study: Evidence for prostate specific antigen screening in BRCA2 mutation Carriers
Eeles, R (Elsevier, 2019-09-17) -
Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers.
Page, EC; Bancroft, EK; Brook, MN; Assel, M; Hassan Al Battat, M; et al. (ELSEVIER, 2019-09-18)BACKGROUND: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 ... -
Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.
Taylor, AE; Martin, RM; Geybels, MS; Stanford, JL; Shui, I; et al. (WILEY, 2017-01-15)Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian ... -
The Lancet Commission on prostate cancer: planning for the surge in cases.
James, ND; Tannock, I; N'Dow, J; Feng, F; Gillessen, S; et al. (Elsevier BV, 2024-04-27) -
Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology.
Loveday, C; Law, P; Litchfield, K; Levy, M; Holroyd, A; et al. (ELSEVIER SCIENCE BV, 2018-09-01)UNLABELLED: Testicular germ cell tumour (TGCT) is the most common cancer in young men. Multiplex TGCT families have been well reported and analyses of population cancer registries have demonstrated a four- to eightfold ... -
Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
Chen, H; Majumdar, A; Wang, L; Kar, S; Brown, KM; et al. (ELSEVIER, 2021-07-08)Genome-wide association studies (GWASs) have identified thousands of cancer risk loci revealing many risk regions shared across multiple cancers. Characterizing the cross-cancer shared genetic basis can increase our ... -
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.
Mancuso, N; Gayther, S; Gusev, A; Zheng, W; Penney, KL; et al. (NATURE PORTFOLIO, 2018-10-04)Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS ... -
LocusExplorer: a user-friendly tool for integrated visualization of human genetic association data and biological annotations.
Dadaev, T; Leongamornlert, DA; Saunders, EJ; Eeles, R; Kote-Jarai, Z (OXFORD UNIV PRESS, 2016-03-15)UNLABELLED: : In this article, we present LocusExplorer, a data visualization and exploration tool for genetic association data. LocusExplorer is written in R using the Shiny library, providing access to powerful R-based ... -
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2.
Silvestri, V; Barrowdale, D; Mulligan, AM; Neuhausen, SL; Fox, S; et al. (BMC, 2016-02-09)BACKGROUND: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 ... -
Management of patients with advanced prostate cancer-metastatic and/or castration-resistant prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022.
Gillessen, S; Bossi, A; Davis, ID; de Bono, J; Fizazi, K; et al. (ELSEVIER SCI LTD, 2023-05-01)BACKGROUND: Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant ... -
Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022.
Gillessen, S; Bossi, A; Davis, ID; de Bono, J; Fizazi, K; et al. (ELSEVIER, 2023-03-01)BACKGROUND: Innovations in imaging and molecular characterisation and the evolution of new therapies have improved outcomes in advanced prostate cancer. Nonetheless, we continue to lack high-level evidence on a variety of ... -
Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021.
Gillessen, S; Armstrong, A; Attard, G; Beer, TM; Beltran, H; et al. (ELSEVIER, 2022-07-01)BACKGROUND: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but various areas of management still lack high-level evidence to inform clinical practice. ... -
Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019.
Gillessen, S; Attard, G; Beer, TM; Beltran, H; Bjartell, A; et al. (ELSEVIER, 2020-04-01)BACKGROUND: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but there are still many aspects of management that lack high-level evidence to inform ... -
Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.
Gillessen, S; Attard, G; Beer, TM; Beltran, H; Bossi, A; et al. (ELSEVIER SCIENCE BV, 2018-02-01)BACKGROUND: In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular characterisation have resulted in multiple areas where there is lack of evidence or low level of ... -
Marital status and prostate cancer incidence: a pooled analysis of 12 case-control studies from the PRACTICAL consortium.
Salmon, C; Song, L; Muir, K; UKGPCS Collaborators,; Pashayan, N; et al. (SPRINGER, 2021-07-18)While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote ... -
Men with a susceptibility to prostate cancer and the role of genetic based screening.
Eeles, R; Ni Raghallaigh, H (AME PUBL CO, 2018-02-01)Prostate cancer is the second most common malignancy affecting men worldwide, and the commonest affecting men of African descent. Significant diagnostic and therapeutic advances have been made in the past decade. Improvements ...