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Now showing items 4349-4355 of 4355
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X-inactivation patch size in human female tissue confounds the assessment of tumor clonality
(2003-03-18)Most models of tumorigenesis assume that tumors are monoclonal in origin. This conclusion is based largely on studies using X chromosome-linked markers in females. One important factor, often ignored in such studies, is ... -
XR5967, a novel modulator of plasminogen activator inhibitor-1 activity, suppresses tumor cell invasion and angiogenesis in vitro
(2004-01)Recent reports suggest that elevated levels of plasminogen activator inhibitor (PAI)-1 may contribute to tumor progression. We have recently shown that antibodies to PAI-1 block the invasive and migratory potential of human ... -
Yeast Phosducin-Like Protein 2 Acts as a Stimulatory Co-Factor for the Folding of Actin by the Chaperonin CCT via a Ternary Complex
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2009-08-07)The eukaryotic chaperonin-containing TCP-1 (CCT) folds the cytoskeletal protein actin. The folding mechanism of this 16-subunit, 1-MDa machine is poorly characterised due to the absence of quantitative in vitro assays. We ... -
Yes-associated protein (YAP) functions as a tumor suppressor in breast
(NATURE PUBLISHING GROUP, 2008-11)Yes-associated protein (YAP) has been shown to positively regulate p53 family members and to be negatively regulated by the AKT proto-oncogene product in promoting apoptosis. On the basis of this function and its location ... -
αB-crystallin Expression in Breast Cancer is Associated with Brain Metastasis.
(2015-10)<h4>Background/objectives</h4>The molecular chaperone αB-crystallin is expressed in estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 "triple-negative" breast carcinomas and promotes ... -
β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.
(2013-07)Although ERBB2 amplification and overexpression is correlated with poor outcome in breast cancer, the molecular mechanisms underlying the aggressive nature of these tumors has not been fully elucidated. To investigate this ...
