Browsing by author "Rivens, Ian"
Now showing items 1-19 of 19
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3D tumour spheroids for the prediction of the effects of radiation and hyperthermia treatments.
Brüningk, SC; Rivens, I; Box, C; Oelfke, U; Ter Haar, G (NATURE PORTFOLIO, 2020-02-03)For multimodality therapies such as the combination of hyperthermia and radiation, quantification of biological effects is key for dose prescription and response prediction. Tumour spheroids have a microenvironment that ... -
A cellular automaton model for spheroid response to radiation and hyperthermia treatments.
Brüningk, SC; Ziegenhein, P; Rivens, I; Oelfke, U; Haar, GT (NATURE PORTFOLIO, 2019-11-27)Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response ... -
A comprehensive model for heat-induced radio-sensitisation.
Brüningk, SC; Ijaz, J; Rivens, I; Nill, S; Ter Haar, G; et al. (TAYLOR & FRANCIS LTD, 2017-07-05)Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality ... -
A study of thermal dose-induced autophagy, apoptosis and necroptosis in colon cancer cells.
Mouratidis, PXE; Rivens, I; Ter Haar, G (TAYLOR & FRANCIS LTD, 2015-07-04)PURPOSE: The pleiotropic effects of heat on cancer cells have been well documented. The biological effects seen depend on the temperature applied, and the heating duration. In this study we investigate the cytotoxic effects ... -
Combining radiation with hyperthermia: a multiscale model informed by in vitro experiments.
Brüningk, S; Powathil, G; Ziegenhein, P; Ijaz, J; Rivens, I; et al. (ROYAL SOC, 2018-01-01)Combined radiotherapy and hyperthermia offer great potential for the successful treatment of radio-resistant tumours through thermo-radiosensitization. Tumour response heterogeneity, due to intrinsic, or micro-environmentally ... -
Comparison of Imaging Changes and Pain Responses in Patients with Intra- or Extraosseous Bone Metastases Treated Palliatively with Magnetic Resonance-Guided High-Intensity-Focused Ultrasound.
Giles, SL; Brown, MRD; Rivens, I; Deppe, M; Huisman, M; et al. (ELSEVIER SCIENCE INC, 2019-02-21)PURPOSE: This study compared changes in imaging and in pain relief between patients with intraosseous, as opposed to extraosseous bone metastases. Both groups were treated palliatively with magnetic resonance-guided ... -
Focused ultrasound transducer spatial peak intensity estimation: a comparison of methods.
Civale, J; Rivens, I; Shaw, A; Ter Haar, G (2018-03-07)Characterisation of the spatial peak intensity at the focus of high intensity focused ultrasound transducers is difficult because of the risk of damage to hydrophone sensors at the high focal pressures generated. Hill et ... -
Focused ultrasound transducer spatial peak intensity estimation: a comparison of methods.
Civale, J; Rivens, I; Shaw, A; Ter Haar, G (IOP PUBLISHING LTD, 2018-03-07)Characterisation of the spatial peak intensity at the focus of high intensity focused ultrasound transducers is difficult because of the risk of damage to hydrophone sensors at the high focal pressures generated. Hill et ... -
Focused Ultrasound-Mediated Hyperthermia in Vitro: An Experimental Arrangement for Treating Cells under Tissue-Mimicking Conditions.
Brüningk, SC; Rivens, I; Mouratidis, P; Ter Haar, G (ELSEVIER SCIENCE INC, 2019-12-01)An experimental arrangement that allows in vitro exposure of cells to focused ultrasound-mediated hyperthermia (43°C-55°C) in a tissue-mimicking phantom with biological, acoustic and thermal properties comparable to those ... -
Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion.
Shaw, CJ; Rivens, I; Civale, J; Botting, KJ; Allison, BJ; et al. (ROYAL SOC, 2019-05-31)High-intensity focused ultrasound (HIFU) is a non-invasive method of selective placental vascular occlusion, providing a potential therapy for conditions such as twin-twin transfusion syndrome. In order to translate this ... -
MR guided high intensity focused ultrasound (MRgHIFU) for treating recurrent gynaecological tumours: a pilot feasibility study.
Giles, SL; Imseeh, G; Rivens, I; Ter Haar, GR; Taylor, A; et al. (BRITISH INST RADIOLOGY, 2019-05-16)OBJECTIVE: To assess the feasibility of targeting recurrent gynaecological tumours with MR guided high intensity focused ultrasound (MRgHIFU). METHODS: 20 patients with recurrent gynaecological tumours were prospectively ... -
Noninvasive high-intensity focused ultrasound treatment of twin-twin transfusion syndrome: A preliminary in vivo study.
Shaw, CJ; Civale, J; Botting, KJ; Niu, Y; Ter Haar, G; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2016-07-13)We investigated the efficacy, maternofetal responses, and safety of using high-intensity focused ultrasound (HIFU) for noninvasive occlusion of placental vasculature compared to sham treatment in anesthetized pregnant ... -
Quantitative photoacoustic imaging study of tumours in vivo: Baseline variations in quantitative measurements.
Martinho Costa, M; Shah, A; Rivens, I; Box, C; O'Shea, T; et al. (ELSEVIER GMBH, 2019-03-01)Photoacoustic imaging (PAI) provides information on haemoglobin levels and blood oxygenation (sO2). To facilitate assessment of the variability in sO2 and haemoglobin in tumours, for example in response to therapies, the ... -
'Relationship between thermal dose and cell death for "rapid" ablative and "slow" hyperthermic heating'.
Mouratidis, PXE; Rivens, I; Civale, J; Symonds-Tayler, R; Ter Haar, G (TAYLOR & FRANCIS LTD, 2019-01-01)AIM: Thermal isoeffective dose (TID) has not been convincingly validated for application to predict biological effects from rapid thermal ablation (e.g., using >55 °C). This study compares the classical method of quantifying ... -
Response to comment by G. Borasi.
Brüningk, SC; Rivens, I; Nill, S; Ter Haar, G; Oelfke, U (TAYLOR & FRANCIS LTD, 2017-08-16) -
The Feasibility of Thermal Imaging as a Future Portal Imaging Device for Therapeutic Ultrasound.
Miloro, P; Civale, J; Rivens, I; Shaw, A (ELSEVIER SCIENCE INC, 2016-08-01)This technical note describes a prototype thermally based portal imaging device that allows mapping of energy deposition on the surface of a tissue mimicking material in a focused ultrasound surgery (FUS) beam by using an ... -
Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound.
Shaw, CJ; Rivens, I; Civale, J; Botting, KJ; Ter Haar, G; et al. (NATURE PORTFOLIO, 2018-09-11)Pre-clinically, High Intensity Focused Ultrasound (HIFU) has been shown to safely and effectively occlude placental blood vessels in the acute setting, when applied through the uterus. However, further development of the ... -
Ultrasound-guided High Intensity Focused Ultrasound (HIFU) ablation of placental vasculature
Shaw, CJ; Civale, J; Giussani, DA; Rivens, I; ter Haar, G; et al. (WILEY-BLACKWELL, 2015-04-01) -
Value of diffusion-weighted imaging for monitoring tissue change during magnetic resonance-guided high-intensity focused ultrasound therapy in bone applications: an ex-vivo study.
Giles, SL; Winfield, JM; Collins, DJ; Rivens, I; Civale, J; et al. (SPRINGERNATURE, 2018-05-10)BACKGROUND: Magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) can palliate metastatic bone pain by periosteal neurolysis. We investigated the value of diffusion-weighted imaging (DWI) for monitoring ...